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水相一锅煮合成1,3,4-噁二唑-5-硫醚类化合物
引用本文:闫旭,葛泽梅,程铁明,李润涛.水相一锅煮合成1,3,4-噁二唑-5-硫醚类化合物[J].中国药学,2008,17(4):277-280.
作者姓名:闫旭  葛泽梅  程铁明  李润涛
作者单位:北京大学 天然药物及仿生药物国家重点实验室,药学院 化学生物学系
基金项目:Foundation items: Natural Science Foundation of China (Grant No. 20672009) and the Major State Basic Research Development Program (Grant No. 2004CB719900).
摘    要:此文报道了由酰肼,二硫化碳及卤代烃或α,β-不饱羰基化合物在水相中——锅煮反应合成1,3,4-噁二唑-5-硫醚类化合物的方法。该方法具有高效、反应条件温和、操作简单、适用范围广和环境友好等优点。

关 键 词:1    3  4-噁二唑-5-硫醚  一锅煮合成  环境友好  水相  酰肼  磷酸钾

One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water
Xu Yan Ze-Mei Ge Tie-Ming Cheng Run-Tao Li The State Key Laboratory of Natural and Biomimetic Drugs.One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water[J].Journal of Chinese Pharmaceutical Sciences,2008,17(4):277-280.
Authors:Xu Yan Ze-Mei Ge Tie-Ming Cheng Run-Tao Li The State Key Laboratory of Natural and Biomimetic Drugs
Institution:Xu Yan Ze-Mei Ge Tie-Ming Cheng Run-Tao Li The State Key Laboratory of Natural and Biomimetic Drugs,Department of Chemical Biology,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China
Abstract:An efficient and environmental-friendly one-pot procedure has been developed for the synthesis of 1,3,4-oxadiazole-5- thioethers by the reaction of acylhydrazine with carbon disulfide and organic halides or α, β-unsaturated carbonyl compounds. The reactions were carried out in water in the presence of potassium phosphate within 2-4 h to afford the expected products in excellent yields.
Keywords:1  3  1  3  4-Oxadiazole-5-thioether  One-pot synthesis  Environmental-friendly  Aqueous medium  Acylhydrazine  Potassium phosphate
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