| Synthesis of Sedative-hypnotic Zopiclone Analogues |
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| 作者姓名： | 左代姝 吕达 刘玉兰 张亚芳 |
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| 作者单位： | 沈阳药科大学有机化学教研室，山东天达药业公司 |
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| 摘 要： | 本文根据环吡咯酮类催眠药佐匹克隆的构效关系及作用机制，合成了八个未见文献报道的环吡咯酮类新化合物，并进行了初步的药效研究。
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| 关 键 词： | 环吡咯酮类化合物 翻正反射实验 镇静催眠 |
Synthesis of Sedative hypnotic Zopiclone Analogues |
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| Dai Shu Zuo ,Da Lu ,Yu Lan Liu and Ya Fang Zhang . Shenyang Pharmaceutical University, . Shandong Tian Da Pharmaceutical Co. Ltd.Synthesis of Sedative-hypnotic Zopiclone Analogues[J].Journal of Chinese Pharmaceutical Sciences,1997(1). |
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| Authors: | Dai Shu Zuo Da Lu Yu Lan Liu and Ya Fang Zhang Shenyang Pharmaceutical University Shandong Tian Da Pharmaceutical Co Ltd |
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| Institution: | Dai Shu Zuo 1,Da Lu 2,Yu Lan Liu 1 and Ya Fang Zhang 1 1. Shenyang Pharmaceutical University,110015, 2. Shandong Tian Da Pharmaceutical Co. Ltd,261500 |
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| Abstract: | Eight new cyclopyrrolone compounds were synthesized according to the structure activity relationship and action mechanism of Zopiclone, a cyclopyrrolone hypnotic. Their preliminary pharmacodynamics are under investigation. |
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| Keywords: | Cyclopyrrolone compounds Righting reflex Sedative hypnotic |
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