| 电喷雾离子阱多级质谱对两个含二硫代羰基的双哌嗪双季铵盐裂解方式研究 |
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| 引用本文： | 王欣,葛泽梅,程铁明,李润涛.电喷雾离子阱多级质谱对两个含二硫代羰基的双哌嗪双季铵盐裂解方式研究[J].中国药学,2004,13(1):24-27. |
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| 作者姓名： | 王欣 葛泽梅 程铁明 李润涛 |
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| 作者单位： | 北京大学药学院 北京100083
(王欣，葛泽梅，程铁明)，北京大学药学院 北京100083(李润涛) |
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| 摘 要： | 目的研究含二硫代羰基的双哌嗪双季铵盐的裂解方式.方法电喷雾离子阱多级质谱.结果 M2 Cl-] 碎片呈现双峰,M2 -CH 3] 离子丰度较低,同时发现M2 Cl--Cl--PhCH2 ] 丰度最高且来源于M2 Cl-] ,其碎片裂解机制由多级质谱证明.
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| 关 键 词： | 二硫代羰基双哌嗪双季铵盐 电喷雾离子阱多级质谱 裂解途径 |
Fragmentation Patterns of Diquaternary Dipiperaziniums Containing Dithiocarboxyl Groups by Electrospray Ionization Tandem Mass Spectrometry |
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| WANG Xin,GE Ze-Mei,Cheng Tie-ming,LI Run-Tao.Fragmentation Patterns of Diquaternary Dipiperaziniums Containing Dithiocarboxyl Groups by Electrospray Ionization Tandem Mass Spectrometry[J].Journal of Chinese Pharmaceutical Sciences,2004,13(1):24-27. |
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| Authors: | WANG Xin GE Ze-Mei Cheng Tie-ming LI Run-Tao |
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| Abstract: | AimTo analyze the fragmentation patterns of diquaternary dipiperaziniums containing dithiocarboxyl groups. MethodsPositive ion electrospray ioniz ation mass spectrometry in conjunction with tandem mass spectrometry (ESI-MS n ) was used. ResultsThe fragment ion M 2 Cl -] showed characteristic double peaks with high intensity instead of the parent molecular ion being detected. And M 2 -CH 3] ion had relatively low intens ity. Meanwhile, M 2 Cl --Cl --PhCH 2] species had the highest i ntensity as the base peak, which was originated from M 2 Cl -] . The detailed fragmentation mechanisms are supported with the tandem mass spectrometr y. |
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| Keywords: | diquaternary dipiperazinium dithiocarboxyl group ESI-MSn fragmentation pathway |
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