| 海洋细菌Bacillus licheniformis中环脂肽类化合物的结构鉴定 |
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| 引用本文： | 高都,;田黎,;柏建,;徐岷涓,;冯蕾,;张庆英,;林文翰.海洋细菌Bacillus licheniformis中环脂肽类化合物的结构鉴定[J].中国药学,2014,23(8):525-532. |
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| 作者姓名： | 高都 ;田黎 ;柏建 ;徐岷涓 ;冯蕾 ;张庆英 ;林文翰 |
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| 作者单位： | [1]北京大学医学部天然药物及仿生药物国家重点实验室,北京100191; [2]国家海洋局第一海洋研究所,山东青岛266061; [3]青岛科技大学,山东青岛266042; [4]上海交通大学系统生物医学研究院,上海200240; [5]上海交通大学分析测试中心,上海200240 |
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| 基金项目： | Foundation items： Grants from COMRA （Grant No. DY125-15-T-01） and SOA （Grant No. 2010319123366025-4）, National High Technology Development Project （863 Project, Grant No. 2011AA10A202-2）, National Key Technologies R＆D Program （Grant No. 2011BAE06B04）.
The present work was supported by the grants from COMRA （Grant No. DY125-15-T-01） and SOA （Grant No. 2010319123366025-4）, National High Technology Development Project （863 Project, Grant No. 2011AA- 10A202-2）, National Key Technologies R＆D Program （Grant No. 2011BAE06B04）. |
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| 摘 要： | 从海洋细菌Bacus licheniformis 代谢产物中首次分离得到2个新表面活性肽（1，2），以及2个已知化合物（3，4）。应用现代NMR技术解析了它们的化学结构，并应用化学与色谱相结合方法确定了氨基酸的构型。论文还探讨该类化合物的质谱裂解规律，为环脂肽类化合物的结构解析提供了快速分析方法。
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| 关 键 词： | 海洋细菌 Bacillus licheniformis枯草芽孢杆菌 环脂肽 surfactin表面活性肽 UPLC-ESI-MS/MS |
Isolation and characterization of cyclic lipopeptides from the marine-derived Bacillus licheniformis |
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| Du Gao,Li Tian,Jian Bai,Minjuan Xu,Lei Feng,Qingying Zhang,Wenhan Lin.Isolation and characterization of cyclic lipopeptides from the marine-derived Bacillus licheniformis[J].Journal of Chinese Pharmaceutical Sciences,2014,23(8):525-532. |
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| Authors: | Du Gao Li Tian Jian Bai Minjuan Xu Lei Feng Qingying Zhang Wenhan Lin |
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| Institution: | Du Gao, Li Tian, Jian Bai, Minjuan Xu, Lei Feng, Qingying Zhang , Wenhan Lin( 1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 10019 I, China 2. The First Institute of Oceanography, State Oceanic Administration (SOA), Qingdao 266061, China 3. Qingdao University of Science ＆ Technology, Qingdao 266042, China 4. Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China 5. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China) |
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| Abstract: | Chromatographic separation of the marine-derived bacterium Bacillus licheniformis resulted in the isolation of two new cyclic lipopeptides named ai-Cl6 surfactin （1） and ai-Cl4 surfactin （2）, together with iso-Cm5 surfactin and iso-Cl6 surfactin. The structures of the new cyclic lipopeptides were determined through extensive spectroscopic analysis. The sequences of the amino acids in cyclic nucleus were established by the ESI-MS/MS fragmentation, which provided an efficient method to detect lipopeptides from bacterium extracts without senaration |
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| Keywords: | Marine-derived bacterium Bacillus licheniformis Cyclic lipopeptides ai-Cl6 surfactin ai-C14 surfactin UPLC-ESI-MS/MS fragmentation |
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