| 载药纳米粒透过血脑屏障机制的研究进展 |
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| 引用本文： | 王斌艳,夏爱晓,陈苹苹,倪玲,刘福和,李范珠.载药纳米粒透过血脑屏障机制的研究进展[J].国外医学(药学分册),2010(1):40-42. |
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| 作者姓名： | 王斌艳 夏爱晓 陈苹苹 倪玲 刘福和 李范珠 |
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| 作者单位： | 浙江中医药大学药学院; |
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| 基金项目： | 国家自然科学基金资助项目(30772793,30371781) |
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| 摘 要： | 血脑屏障是维持中枢神经系统内环境稳定的结构基础,有效保护脑组织避免外源性有害物质侵害,但也阻碍许多治疗药物进入脑内,限制了中枢神经系统药物的临床应用。如何有效透过血脑屏障成为此类药物发挥治疗作用的关键环节。纳米粒作为一种新型药物载体,能携载药物透过血脑屏障进入脑组织,提高脑内药物浓度,实现脑内靶向给药。本文对载药纳米粒及其透过血脑屏障机制的研究进展作一综述。
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| 关 键 词： | 纳米粒 血脑屏障 中枢神经系统药物 药物载体 |
Blood-brain barrier transport of drug-loaded nanoparticle:research advances |
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| WANG Bin-yan,XIA Ai-xiao,CHEN Ping-ping,NI Ling,LIU Fu-he,LI Fan-zhu.Blood-brain barrier transport of drug-loaded nanoparticle:research advances[J].Foreign Medical Sciences(Section of Pharmarcy),2010(1):40-42. |
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| Authors: | WANG Bin-yan XIA Ai-xiao CHEN Ping-ping NI Ling LIU Fu-he LI Fan-zhu |
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| Institution: | Department of Pharmaceutics;Zhejiang Chinese Medical University;Hangzhou 310053;China |
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| Abstract: | The blood-brain barrier(BBB)is the basic stucture to maintain homoestasis of the central nervous system,which has protective effect on brain tissue,but prevents many drugs into the brain,resulting in the limited clinical application of these drugs.How to effectively deliver the drugs through BBB has become a key step.As a novel drug-loaded carrier,nanoparticle can carry drugs through the BBB and increase the drug concentration in the brain,so as to achieve brain targeted drug delivery.This article briefly r... |
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| Keywords: | nanoparticle blood-brain barrier central nervous system agents drug carrier |
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