半夏泻心汤联合甘精胰岛素注射液对脾弱胃强型2型糖尿病患者血糖及免疫指标的影响

目的考察半夏泻心汤联合甘精胰岛素注射液对脾弱胃强型2型糖尿病患者血糖及免疫指标的影响。方法选取2019年1月~2020年12月于天津市河西区康复医院诊治的脾弱胃强型2型糖尿病患者120例,随机分为对照组和观察组,每组60例,对照组仅给予甘精胰岛素注射液,观察组给予半夏泻心汤联合甘精胰岛素注射液。比较两组治疗后1个月和3个月患者临床治疗有效率,治疗前、治疗后1个月和3个月糖化血红蛋白(glycosylated hemoglobin,HbA1c)和空腹血糖(fasting plasma glucose,FPG)及免疫细胞CD3⁺、CD4⁺、CD8⁺和CD4⁺/CD8⁺水平。结果相比于对照组,观察组治疗后1个月和3个月临床治疗有效率显著提高(P<0.05);两组治疗前血糖和免疫相关指标相比,差异无统计学意义(P>0.05),治疗后1个月和3个月,两组患者HbA1c、FPG和CD8⁺相比于治疗前均显著降低,而CD3⁺、CD4⁺和CD4⁺/CD8⁺显著升高(P<0.05);治疗后3个月,两组患者HbA1c、FPG和CD8⁺相比于治疗后1个月均显著降低,而CD3⁺、CD4⁺和CD4⁺/CD8⁺显著升高(P<0.05);观察组治疗后1个月和3个月HbA1c、FPG和CD8⁺相比于对照组均显著降低,而CD3⁺、CD4⁺和CD4⁺/CD8⁺显著升高(P<0.05)。结论半夏泻心汤联合甘精胰岛素注射液治疗脾弱胃强型2型糖尿病患者的临床效果较好,能够有效降低患者血糖水平,改善机体免疫水平。

Effect of Banxia Xiexin Decoction combined Insulin glargine injection on blood glucose and immune indexes of spleen weak stomach strong type 2 diabetes mellitus

Objective To investigate the effect of Banxia Xiexin Decoction combined Insulin glargine injection on blood glucose and immune indexes of type 2 diabetes mellitus with weak spleen and strong stomach.Methods 120 patients were selected with type 2 diabetes with weak spleen and strong stomach treated in Tianjin Hexi Rehabilitation Hospital from January 2019 to December 2020,randomly divided into control group and observation group,60 cases in each group,the control group was given Insulin glargine injection,observation group was given Banxia Xiexin decoction combined Insulin glargine injection.Compare with the clinical effective rate of the two groups.the HbA1c,FPG and the level of CD3⁺,CD4⁺,CD8⁺and CD4⁺/CD8⁺of immune cell in 2 groups before treatment,at 1 and 3 months after treatment.Results Compared with the control group,the clinical effective rate of observation group was significantly increased at 1 and 3 months after treatment(P<0.05);There were no significant differences in blood glucose and immune-related indexes between 2 groups before treatment(P>0.05).HbA1c,FPG and CD8⁺was significantly decreased in 2 groups at 1 and 3 months after treatment,while CD3⁺,CD4⁺and CD4⁺/CD8⁺was significantly increased(P<0.05).3 months after treatment,HbA1c,FPG and CD8⁺were significantly decreased in 2 groups compared with 1 month after treatment,while CD3⁺,CD4⁺and CD4⁺/CD8⁺was significantly increased(P<0.05).Compared with the control group,HbA1c,FPG and CD8⁺was significantly decreased in the observation group at 1 and 3 months after treatment,while CD3⁺,CD4⁺and CD4⁺/CD8⁺was significantly increased(P<0.05).Conclusion Banxia Xiexin Decoction combined with Insulin glargine injection has a good clinical effect in the treatment of type 2 diabetes patients with weak spleen and strong stomach,which can effectively reduce the blood glucose level of patients and improve the immune level of the body.