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| 阿魏酸钠双层片的制备及体外释放特性 | |
| 引用本文： | 胡静波,陈鹰,苏卫,胡晓,董少华.阿魏酸钠双层片的制备及体外释放特性[J].中国药师,2012,15(6):808-810. |
| 作者姓名： | 胡静波 陈鹰 苏卫 胡晓 董少华 |
| 作者单位： | 1. 广州军区武汉总医院,武汉,430070;南方医科大学 2. 广州军区武汉总医院,武汉,430070 3. 广州军区武汉总医院,武汉,430070;湖北中医药大学 |
| 摘 要： | 目的:制备阿魏酸钠双层片并考察其体外释放特性.方法:采用粉末直接压片法,以羟丙基甲基纤维素(HPMC)为骨架材料制备阿魏酸钠双层片,通过紫外分光光度法,按照<中国药典>的转篮法测定体外释放度,并对体外药物释放的影响因素进行考察.结果:HPMC的规格和用量是影响药物释放的主要因素,填充剂不同对药物的释放也产生一定影响.结论:以HPMC K15M为骨架材料,微晶纤维素为填充剂制备的阿魏酸钠双层片具有良好的缓释和速释特性. |
| 关 键 词： | 阿魏酸钠 双层片 制备 体外释放 |
| 收稿时间： | 2012/1/10 0:00:00 |
| 修稿时间： | 2012/3/23 0:00:00 |
Studies on Preparation and in vitro Drug Release of Sodium Ferulate Double-layer Tablets |
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| Hu Jingbo , Chen Ying , Su Wei , Hu Xiao , Dong Shaohua.Studies on Preparation and in vitro Drug Release of Sodium Ferulate Double-layer Tablets[J].China Pharmacist,2012,15(6):808-810. | |
| Authors: | Hu Jingbo Chen Ying Su Wei Hu Xiao Dong Shaohua |
| Institution: | Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China; Southern Medical University;;Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China;;Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China; Southern Medical University;;Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China; Hubei University of Chinese Medicine;Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China; Hubei University of Chinese Medicine |
| Abstract: | Objective: To prepare sodium ferulate double-layer tablets and study the drug release in vitro.Method: Sodium ferulate double-layer tablets were prepared using HPMC as the matrix by direct powder compression.UV-spectrophotometry and rotating basket method described in the Chinese Pharmacopeia(2010 edition) were used to determine the in vitro dissolution of sodium ferulate double-layer tablets and study the various influence factors.Result: The specification and amount of HPMC were the main impact factors.The diluents showed effects on the drug release of the tablets as well.Conclusion: Sodium ferulate double-layer tablets based on HPMC K15M and microcrystalline cellulose have promising sustained and quick release properties. |
| Keywords: | Sodium ferulate Double-layer tablets Preparation Release behavior in vitro |
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