奥硝唑治疗滴虫性阴道炎患者疗效及安全性观察

探讨奥硝唑治疗滴虫性阴道炎患者的疗效及安全性。方法：112例滴虫性阴道炎患者随机分为观察组和对照1组各56例。对照组予甲硝唑片200mg，po，tid，观察组予奥硝唑片500mg，po，tid，治疗5d。比较两组患者临床疗效、疗状体征评分后不良反应。结果：观察组总有效率为96．4％，高于对照组82．1％（P〈0．05）；治疗后，两组患者各症状评分均较治疗前明显改善（P〈0．05），两组治疗后症状体征评分比较差异无统计学意义（P〉0．05）；观察组不良反应发生率明显低于对照组（P〈0．05）。结论：奥硝唑治疗滴虫性阴道炎，临床疗效显著，且药物不良反应发生率低，患者耐受性好，值得临床推广。

Efficacy and Safety of Ornidazole in the Treatment of Trichomonal Vaginitis

To explore the efficacy and safety of ornidazole in the treatment of trichomonal vaginitis. Methods： Totally 112 cases of trich0monal vaginitis from February 2011 to December 2012 in our hospital were selected and randomlY divided into the observation group and the control group with 56 cases in each. The control group was treated with metronidazole tablets 200mg, po, tid, and the observation group was treated with ornidazole tablets 500mg, po, bid. The treatment course was 7 days. The clinical effect, score of clinical symptoms and incidence of adverse reactions of the two groups were compared. Results： The total effective rate of the observation group was 96.4%, which was higher than that of the control group （82.1% ）, and the difference was statistically significant （P 〈0.05 ）. The symptom scores of the two groups were significantly improved after the treatnlent （P 〈 0.05 ）, however, the score between the two groups showed no significant difference （P 〉 0.05 ）. The incidence rate of adverse reactions in the observation group was 10.71%, which was significantly lower than that in the control group （37.5%）, and the difference was statistically signifi- cant （P 〈 0.05 ）. Conclusion ： The clinical curative effect of ornidazole in the treatment of trichomonal vaginitis is notable with faster onset, shorter treatment course, lower adverse reaction rate and better patient tolerance, which is valuable in the clinical promotion.