300例外科手术患者预防应激性溃疡药物调查

摘 要 目的:了解外科手术患者预防应激性溃疡(SU)药物的情况，评价药物使用合理性，为临床合理用药提供参考。方法: 随机抽取2010年外科住院手术患者病历300份，对预防SU的药物使用情况进行统计、分析。结果:总的预防用药率为18.67%，其中肝胆科的预防用药率最高（63.33%），其次为胸外科、脊柱外科和普外科；儿科和乳腺科的预防用药率为0。300例中，儿科出现应激性溃疡出血1例（0.33%）；预防SU药物中质子泵抑制药使用率最高为91.07%，H₂受体阻断药为5.36% ，黏膜保护药及其他为3.57%。结论:应激性溃疡重在预防，但应掌握适应证，防止药物不合理使用。

Investigation of Stress Ulcer Prevention Drug Use in 300 Cases of Surgical Patients

Objective： To understand the stress ulcer prevention drug usage in the surgical patients to evaluate the application and rationality of the drugs for clinical reference. Method： 300 cases of surgical patients in the year of 2010 were randomly selected and the drug usage was gathered for statistical analysis. Result： The overall rate of prevention drug use was 18.67% , in which hepatobiliary surgery was the highest （63.33%） followed by spine surgery, general surgery and hepatology. The rates of prevention drug use in department of pediatrics and breast were both zero. Only one case in pediatrics appeared ulcer bleeding with the incidence of 0.33%. PPIs was the most frequently used prevention drug as high as 91.07% followed by H2RA （5.36%） , the mueosal protection agents and other drugs （3.57%）. Conclusion： The prevention is the most important in stress ulcer with the premise of indications and rational drug use.