兰索拉唑治疗胃食管反流病的疗效观察

目的:观察兰索拉唑(Lsp)治疗胃食管反流病(GERD)的疗效。方法:随机将141例GERD患者分为Lsp治疗组73例和奥美拉唑(Omp)对照组68例,于治疗4-8周后观察临床症状的缓解,胃内pH值的变化及部分伴有食管炎患者的愈合情况。结果:治疗4周后,Lsp治疗组临床症状中的烧心改善优于对照组(P<0．05);胃内pH升高程度明显优于Omp对照组(P<0．01)。服药第4,8周分别进行胃镜检查,治疗组伴有食管炎患者的愈合与Omp组比较无统计学差异(P>0．05)。结论:Lsp治疗GERD的疗效稍优于Omp。

Effect of Lansoprazole in Treatment of Gastroesophageal Reflux Disease

Objective: To observe the curative effect of the lansoprazole (Lsp) in treatment of the gastroesophageal reflux disease (GERD). Method: Divided 141 GERD patients into Lsp group (73 cases) and omeprazole(Omp) group (68 cases) randomly, which were compared after curing for 4-8 weeks, the relieving of the clinical symptoms and the changes of the pH in the stomach and the recovering of the patients, who suffered with esophagitis wee observed. Result: After treatment for 4 weeks, the improvement in hearthurt in the Lsp group was better than that of the Omp group (P < 0.05 ). The increace of the pH in Lsp group was better than that of the Omp group obviously( P <0.01). On the 4th and 8th week, stomachoscopy examination in the patients who suffered from esophagitis were no statistic difference in two groups(P >0.05). Conclusion: Lsp is a little superior to Omp in the therapeutic effect of GERD.