大鼠口服雄黄后砷的药物动力学与毒代动力学研究

目的：探讨大鼠口服不同剂量雄黄后砷的药动学及毒代动力学规律。方法：氢化物发生．原子荧光光谱法测定大鼠单次灌胃3．5g·kg^-1和7．0g·kg^-1。雄黄后不同时间的血及组织中砷含量，拟合药动学模型，计算药动学参数。结果：大鼠单次口服雄黄后砷的药动学特征符合一室模型，3．5g·kg^-1和7．0g·kg^-1两个剂量组主要药动学和毒代动力学参数分别为：t1／2：15．87h和16．87h；Cmax：3．74×10^2μg·L^-1和6．89×10^2μg·L^-1；AUC0—6：9．86×10^3μg·h·L^-1和1．69×10^4μg·h·L^-1。砷在各组织均有分布，以肝、肾中含量最高。结论：大鼠口服不同剂量雄黄后砷在大鼠血中的药动学过程基本一致，在体内可造成蓄积。

Pharmacokinetics and Toxicokinetics of Arsenic after Oral Administration of Realgar in Rats

Objective ： To study the pharmacokinetics and the toxicokinetics of arsenic in rats after oral administration of realgar. Method： Hydride generation on-line coupled with atomic fluorescence spectrometry method was used for determination of arsenic in the blood and tissues of rats after oral administration of realgar with different dosage （3.5 g · kg^-1 and 7.0 g · kg^-1 ）. Compartment model was fitted and the pharmacokinetic parameters were calculated with data from blood. Result： Arsenic showed single compartment model in rats and the main pharmacokinetic parameters and toxicokinetics parameters of tow and high dose were as follows ： t1/2 ： 15.87 h, 16.87 h;Cmax ：3.74 × 10^2 μg · L^-1, 6.89 × 10^2 μg · L^-1 ;AUC0 6：9.86 × 10^3 μg · h · L^-1 , 1.69 × 10^4μg · h · L^-1 respectively. The distribution of Arsenic in each tissue, however the contents in liver and kidney were highest. Condusion： The pharmaeokinetics course of arsenic in rat after oral administration of realgar in different dose is similar, and there was possibility of accumulation of arsenic in rats.