基于微管靶点的抗肿瘤药物研究进展

摘 要微管是存在于所有真核细胞中构成细胞骨架的重要组成成分，其能与其他的蛋白组装成纺锤体、中心粒和神经管等结构。微管在细胞生长、维持形态、细胞信号传导，尤其在有丝分裂过程中起到重要的作用。微管是新药发现的重要靶点。作用于微管的抗肿瘤药物是一类最有效的应用于临床的药物，该类药物抑制微管聚合、破坏微管动态不平衡性、破坏纺锤体、阻滞细胞周期，引起肿瘤细胞死亡。本文综述了以微管为靶点的抗肿瘤药物及其作用机制，并对以微管为靶点的肿瘤治疗药物的应用前景进行展望。

Research Progress in Anti tumor Drugs Based on Microtubules Targets

ABSTRACTMicrotubules are the important components in cytoskeleton, which are found in all eukaryotic cells. Microtubules can assemble with the other proteins to form spindle, centriole and neural tube structure. Microtubules play important roles in cell mitosis, intracellular transportation, cell shape maintenance and signal transduction process. Microtubules are the important targets in many drug discoveries. The antitumor drugs acting on microtubules are the most effective clinical drugs, which can inhibit the polymerization of microtubules, destroy microtubules dynamic balance and spindle, block cell cycle and induce tumor cells necrosis. The paper reviewed the effects and action mechanisms of microtubules targeted antitumor drugs, and discussed their application prospects in clinics.