泮托拉唑治疗消化性溃疡临床疗效观察

目的：研究泮托拉唑与奥美拉唑治疗消化性溃疡的疗效及安全性。方法：经胃镜证实的消化性溃疡患者随机分成泮托拉唑组（治疗组）62例和奥美拉唑组（对照组）58例。治疗组泮托拉唑40mg，po，qn，对照组用药为奥美拉唑20mg，po，qn。十二指肠溃疡患者疗程4周，胃溃疡患者疗程6周。停药后均复查胃镜观察溃疡愈合情况。症状改善及副作用发生情况。结果：十二指肠溃疡的愈合率两组分别为92．1％和94．7％，胃溃疡的愈合率两组分别为91．7％和90％（P均〉0．05）。各项症状的改善情况两组无统计学差异。副作用的发生率两组分别为9．7％和8．6％（P〉0．05）。结论：泮托拉唑对消化性溃疡有较高的治愈率和良好的症状改善情况，其疗效和副作用与奥美拉唑相当。

Clinic Effect of Pantoprazole on Treatment of Peptic Ulcer

Objective： To study the effect and safety of pantoprazole on treatment of peptic ulcer. Method： Patients with peptic ulcer diagnosed by endoscope were randomly divided into pantoprazole group （treatment group） 62 cases and omeprazole group （control group）58 cases. The treatment group received pantoprazole 40 mg, po, qn and the control group received omeprazole 20 mg, po,qn. The course of duodenal ulcer was 4 weeks and gastric ulcer was 6 weeks. Result： After 4 weeks of treatment the healing rates of duodenal ulcer were 92.1% in patients given pantoprazole and 94.7% in the omeprazole group（P 〉0.05）. After 6 weeks, the healing rates of gastric ulcer were 91.7% in the pantoprazole group and 90% in the omeprazole group（ P 〉 0.05 ）. The syndrome reliefed rates and the incidence of ADR had no statistical difference in two groups. Conclusion： Pantoprazole has higher therapeutic effects on treatment of peptic ulcer and the healing rates are equivalent to omeprazole.