| 正交试验优选黄连提取工艺 |
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| 引用本文： | 黄传俊,李其兰,高申蓉,陈红专.正交试验优选黄连提取工艺[J].中国药师,2005,8(8):699-700. |
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| 作者姓名： | 黄传俊 李其兰 高申蓉 陈红专 |
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| 作者单位： | 1. 湖北省中医院,武汉,430061
2. 湖北中医学院 |
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| 摘 要： | 目的:优选黄连最佳提取工艺.方法:采用正交试验法,以黄连提取的收膏率和盐酸小檗碱提取量为考察指标,利用HPLC法测定盐酸小檗碱的含量.结果:最佳提取工艺为黄连粗粉加8倍量60%的乙醇回流提取3次,每次1 h.结论:优选得到的工艺简便易行,稳定性好.
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| 关 键 词： | 黄连 盐酸小檗碱 提取工艺 正交试验 |
| 文章编号： | 1008-049X（2005）08-0699-02 |
| 收稿时间： | 2004-11-02 |
| 修稿时间： | 2004年11月2日 |
Optimization of Extraction Process of Rhizoma Coptis with Orthogonal Design Method |
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| Huang Chuan Jun,LI Qilan,Gao Shen Rong,Chen Hongzhuan.Optimization of Extraction Process of Rhizoma Coptis with Orthogonal Design Method[J].China Pharmacist,2005,8(8):699-700. |
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| Authors: | Huang Chuan Jun LI Qilan Gao Shen Rong Chen Hongzhuan |
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| Abstract: | To optimize the best extraction process of Rhizoma Coptis. Method: Using orthogonal design method, to apply extract yield of Rhizoma Coptis and the extract amount of berberine hydrochloride as observing indexes, to measure the content of berberine hydrochloride with HPLC. Result; The optimum extraction process was as follows, adding 8 times of 60% alcohol into coptis meal, refluxing and extracting for 3 times ,one hour every time. Conclusion; This optimized process is simple, stable and efficient. |
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| Keywords: | Rhizoma Coptis Berberine hydrochloride Extraction process Orthogonal design |
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