| 缬草抗心律失常活性部位的筛选 |
| |
| 引用本文： | 段雪云,方颖,龚占峰,周颖,刘焱文.缬草抗心律失常活性部位的筛选[J].中国药师,2009,12(7):842-844. |
| |
| 作者姓名： | 段雪云 方颖 龚占峰 周颖 刘焱文 |
| |
| 作者单位： | 1. 湖北中医学院"中药资源与中药复方"省部共建教育部重点实验室,武汉,430061;湖北省中医院
2. 湖北中医学院"中药资源与中药复方"省部共建教育部重点实验室,武汉,430061 |
| |
| 基金项目： | 国家自然科学基金项目 |
| |
| 摘 要： | 目的：筛选缬草抗心律失常的活性部位。方法：建立以氯仿诱导心律失常的小鼠模型，分别灌胃给予缬草不同的提取部位，以小鼠室颤发生率为观察指标。结果：缬草提取物中水液部位和缬草油部位分别在5g（生药）·ml^-1和2．5g（生药）·ml^-1能显著降低氯仿所致小鼠室颤发生率，且水液部位的90％乙醇洗脱物和水洗脱物能显著降低氯仿所致小鼠室颤发生率（P〈0．05）。结论：缬草提取物中水液部位和缬草油有抗心律失常作用。
|
| 关 键 词： | 缬草 缬草提取物 室性纤颤 抗心律失常 |
Screening of Active Site of the Extracts of Valeriana Officinalis L.on Cardiac Arrhythmias |
| |
| Duan Xueyun,Fang Ying,Gong Zhanfeng,Zhou Ying,Liu Yanwen.Screening of Active Site of the Extracts of Valeriana Officinalis L.on Cardiac Arrhythmias[J].China Pharmacist,2009,12(7):842-844. |
| |
| Authors: | Duan Xueyun Fang Ying Gong Zhanfeng Zhou Ying Liu Yanwen |
| |
| Abstract: | Objective： To study the antiarrhythmic effects of extracts of Valeriana offwinalis L. Method： The arrhythmic animal models were caused by trichloromethane. The groups were treated respectively with the extracts of Valeriana officinalis L. and the incidence ratios of ventricular fibrillation （VF） was observed. Result： Water-extracts and essential oil of Valeriana officinalis L. in 5 and 2.5 g·ml^-1 （crude drug） could markedly decreased the ratio of VF caused by trichloromethane in mice, the 90% alcohol eluate and water eluate in water-extract could markedly do so. Conclusion： The water-extract and essential oil of Valeriana officinalis L. are more effective on cardiac arrhythmias. |
| |
| Keywords: | Extracts of Valeriana officinalis L Ventricular fibrillation Antiarrhythmic |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国药师》浏览原始摘要信息 |
| 点击此处可从《中国药师》下载免费的PDF全文 |
|
