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| 连翘酯苷反相硅胶中压制备工艺的优化 | |
| 引用本文： | 徐嘉,杨骏,黄孝春,玄振玉.连翘酯苷反相硅胶中压制备工艺的优化[J].中国药师,2012,15(1):47-50. |
| 作者姓名： | 徐嘉 杨骏 黄孝春 玄振玉 |
| 作者单位： | 1. 复旦大学附属肿瘤医院药剂科,复旦大学上海医学院肿瘤学系 上海,200032 2. 上海卢湾区香山中医医院 3. 上海玉森新药开发有限公司 |
| 摘 要： | 目的:优选连翘叶中连翘酯苷的最佳反相硅胶(RP-18)中压制备工艺条件.方法:采用单因素多水平试验的方法,考察上样量(连翘酯苷粗品/RP-18硅胶)、洗脱流速、柱床径高比等因素对连翘酯苷得量的影响,优选出最佳纯化工艺条件.结果:最佳工艺为上样量(连翘酯苷粗品/RP-18硅胶)为1:50、洗脱流速为1.5 BV·h-1、柱床径高比为1∶10.结论:优选得到的连翘酯苷的最佳反相(RP-18)中压制备工艺简单、稳定、可行. |
| 关 键 词： | 连翘酯苷 反相硅胶(RP-18) 制备工艺 |
| 收稿时间： | 2011/8/15 0:00:00 |
| 修稿时间： | 2011/10/12 0:00:00 |
Optimization of RP Silica Gel (RP-18) Medium Voltage Preparation Technology for Forsythiaside |
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| Xu Ji,Yang Jun,Huang Xiaochun and Xuan Zhenyu.Optimization of RP Silica Gel (RP-18) Medium Voltage Preparation Technology for Forsythiaside[J].China Pharmacist,2012,15(1):47-50. | |
| Authors: | Xu Ji Yang Jun Huang Xiaochun and Xuan Zhenyu |
| Institution: | Fudan University Shanghai Cancer Center, Shanghai 200032, China;Shanghai Luwan District Xiangshan Chinese Medicine Hospital;Shanghai Youseen Drug Development Corporation;Shanghai Youseen Drug Development Corporation |
| Abstract: | Objective ： To establish the optimal RP silica gel （ RP18 ） preparation technology for forsythiaside. Method： A single- factor multi-level experiment was used to screen the optimal purification conditions. The sample amount, eluting velocity and diameter/ height ratio of the column were set as the factors in the test. Result： The optimal purification technology was achieved with the sample/ RP-18 ratio of 1：50, the eluting velocity of 1.5 BV. h- 1 and diameter/height ratio of 1： 10. Conclusion： The optimal purification tech- nology is simple, stable and feasible. |
| Keywords: | Forsythiaside RP silica gel (RP-18) Preparation technology |
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