酒石酸布托啡诺、地佐辛与盐酸托烷司琼在镇痛泵内配伍的稳定性考察

目的:考察酒石酸布托啡诺、地佐辛、盐酸托烷司琼在0.9%氯化钠注射液中的配伍稳定性。方法:模拟临床实际用药的配伍浓度和使用环境,检测0,1,4,6,24,48,72 h外观、pH、相对百分含量的变化。结果:酒石酸布托啡诺、地佐辛与盐酸托烷司琼的配伍液在72 h内pH未出现明显变化,外观稳定,各药品成分相对百分含量也没有明显变化。结论:在室温条件下,酒石酸布托啡诺、地佐辛与盐酸托烷司琼在0.9%氯化钠注射液中72 h内保持稳定。因此,酒石酸布托啡诺(6 mg)、地佐辛(20 mg)与盐酸托烷司琼(10 mg)可以配伍使用,在镇痛泵内配伍稳定。

Stability Studies of Butorphanol Tartrale,Dezocine and Tropisetron Hydrochloride in Patient-controlled Analgesia Pump

Objective:To study the stability of the mixture of butorphanol tartrale,dezocine and tropisetron hydrochloride in 0.9%sodium chloride injection saline.Methods:The compatibility concentration and the use environment of the actual clinical medication were simulated,and the changes of appearance,p H and relative percentage content at 0,1,4,6,24,48 and 72 hours were detected.Results:There were no significant changes of p H value,visible bubbles,precipitation and color in the compatible solution of butorphanol tartrale,dezocine and tropisetron hydrochloride within 72 hours.There was no obvious change in the relative percentage content of each drug component.Conclusion:Butorphanol tartrale,dizocine and tropisetron hydrochloride were stable for 72 hours in 0.9%sodium chloride injection at room temperature.Therefore,butorphanol tartrale(6 mg)and dezocine(20 mg)can be mixed with tropisetron hydrochloride(10 mg),which are stable in the analgesic pump.