| 高迁移率族蛋白1在心肌缺血再灌注损伤中作用的研究进展 |
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| 引用本文： | 陈川斌,黄锋△.高迁移率族蛋白1在心肌缺血再灌注损伤中作用的研究进展[J].天津医药,2020,48(11):1125-1130. |
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| 作者姓名： | 陈川斌 黄锋△ |
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| 作者单位： | 广西医科大学第一附属医院心血管内科（邮编530021） |
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| 摘 要： | 心肌缺血再灌注损伤的发病机制复杂。高迁移率族蛋白1（high mobility group box-1，HMGB1）在心肌缺血再灌注损伤中扮演重要角色，参与炎症反应、细胞凋亡和自噬等过程，成为防治心肌缺血再灌注损伤的潜在干预靶点。本文就HMGB1在心肌缺血再灌注损伤中的作用机制作一综述。
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| 关 键 词： | HMGB1蛋白质 心肌再灌注损伤 细胞凋亡 自噬 炎症反应 |
| 收稿时间： | 2020-06-28 |
| 修稿时间： | 2020-08-09 |
Research progress on the role of high mobility group box-1 in myocardial ischemia
reperfusion injury |
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| CHEN Chuan-bin,HUANG Feng△.Research progress on the role of high mobility group box-1 in myocardial ischemia
reperfusion injury[J].Tianjin Medical Journal,2020,48(11):1125-1130. |
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| Authors: | CHEN Chuan-bin HUANG Feng△ |
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| Institution: | Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; |
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| Abstract: | The pathogenesis of myocardial ischemia reperfusion injury is complex. Recent studies have shown that high mobility group box-1 (HMGB1) plays an important role in myocardial ischemia reperfusion injury and is involved in inflammatory response, apoptosis, autophagy and other processes, which has become a potential intervention target for prevention and treatment of myocardial ischemia reperfusion injury. Therefore, this paper reviews the mechanism of HMGB1 in myocardial ischemia reperfusion injury. |
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| Keywords: | HMGB1 protein myocardial reperfusion injury apoptosis autophagy inflammatory response |
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