| APC-EPCR-PAR1通路在类风湿关节炎中的研究进展 |
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| 引用本文： | 刘轩绮,刘汇洋,赵京洋,尹芳蕊,白力,王永福. APC-EPCR-PAR1通路在类风湿关节炎中的研究进展[J]. 天津医药, 2022, 50(5): 552-556. DOI: 10.11958/20211591 |
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| 作者姓名： | 刘轩绮 刘汇洋 赵京洋 尹芳蕊 白力 王永福 |
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| 作者单位： | 1包头医学院第一附属医院风湿免疫科，包头医学院风湿免疫研究所（邮编014000）；2内蒙古科技大学包头医学院；3内蒙古自治区自体免疫学重点实验室 |
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| 基金项目： | 内蒙古自治区自然科学基金资助项目（2020LH08001,2021BS08006）； |
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| 摘 要： | 类风湿关节炎（RA）是一种慢性、系统性自身免疫性疾病。活化蛋白C（APC）是由其前体蛋白C（PC）转化而来的一种天然抗凝血剂，在凝血调控中起着关键的作用。APC可与内皮蛋白C受体（EPCR）结合，激活内皮细胞上的蛋白激酶受体1（PAR1），从而启动细胞的保护和抗炎反应。现就APC-EPCR-PAR1活化通路上各靶点在RA中的研究进展进行综述，探讨APC-EPCR-PAR1通路在RA疾病中的潜在治疗价值，为RA的治疗提供更多的选择。
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| 关 键 词： | 关节炎 类风湿；蛋白质C；受体 细胞表面；蛋白酪氨酸激酶类；APC-EPCR-PAR1通路 |
| 收稿时间： | 2021-07-08 |
| 修稿时间： | 2021-11-05 |
Research progress of APC-EPCR-PAR1 pathway in rheumatoid arthritis |
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| LIU Xuanqi,LIU Huiyang,ZHAO Jingyang,YIN Fangrui,BAI Li,WANG Yongfu,△. Research progress of APC-EPCR-PAR1 pathway in rheumatoid arthritis[J]. Tianjin Medical Journal, 2022, 50(5): 552-556. DOI: 10.11958/20211591 |
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| Authors: | LIU Xuanqi LIU Huiyang ZHAO Jingyang YIN Fangrui BAI Li WANG Yongfu △ |
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| Affiliation: | 1 Department of Rheumatology and Immunology, the First Affiliated Hospital of Baotou Medical College (Institute of Rheumatology and Immunology, Baotou Medical College), Baotou 014000, China; 2 Baotou Medical College, Inner Mongolia University of Science and Technology; 3 Inner Mongolia Autoimmune Key Laboratory
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| Abstract: | Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease. Activated protein C (APC) is a natural anticoagulant transformed from its precursor protein C (PC), which plays a key role in the regulation of blood coagulation. APC can bind to endothelial protein C receptor (EPCR) and activate protein kinase receptor 1 (PAR1) on endothelial cells, thereby initiating cell protection and anti-inflammatory response. This article summarizes the research progress of each target on the APC-EPCR-PAR1 activation pathway in RA, discusses the potential therapeutic value of APC-EPCR-PAR1 pathway in RA diseases, and provides more options for the treatment of RA in the future. |
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| Keywords: | arthritis rheumatoid protein C receptors cell surface protein-tyrosine kinases APC-EPCR-PAR1 pathway |
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