肠道菌群及其代谢产物氧化三甲胺与心力衰竭关系的研究进展

摘要：肠道菌群及其代谢产物与心力衰竭的发生发展有着密不可分的联系。许多研究表明，肠道代谢产物氧化三甲胺促进心力衰竭的发生，并与心力衰竭的预后密切相关。本文将主要从氧化三甲胺的致心力衰竭病理生理学机制、临床相关研究及基于此的治疗策略等方面进行综述。

Research advances on trimethylamine N-oxide of metabolite of gut flora and heart failure

Intestinal flora and its metabolites are inextricably associated with the development of heart failure (HF)."Gut hypothesis in HF" indicates that patients with cardiovascular diseases encounter gut flora imbalance and bacterial translocation, which can trigger systemic inflammatory response and eventually promote the progression of heart failure. Studies showed that a higher concentration of trimethylamine N-oxide (TMAO), a kind of intestinal metabolites, could induce the occurrence of cardiovascular adverse events through a variety of mechanisms (such as intensifying myocardial fibrosis, ventricular remodeling and progress of coronary plaque, aggravating water-sodium retention and systemic inflammatory response), and which is closely related to the survival and prognosis of patients with HF. These patients could benefit from the reducing TMAO. This article reviews the research advances of the relationship between intestinal flora or TMAO and heart failure.