| 去泛素化酶USP9X促进消化系统肿瘤进展的研究现状 |
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| 引用本文： | 王捷夫,王茜.去泛素化酶USP9X促进消化系统肿瘤进展的研究现状[J].天津医药,2019,47(5):542-548. |
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| 作者姓名： | 王捷夫 王茜 |
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| 作者单位： | 天津医科大学肿瘤医院，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心（邮
编300060） |
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| 摘 要： | 摘要：去泛素化酶9X（USP9X）是去泛素化酶（DUBs）中的一员。USP9X是X染色体连锁的泛素特异性蛋白酶
（USPs），可以通过稳定不同的底物，发挥相应的生物学效应。USP9X在信号通路转导、细胞生长及迁移、免疫应答、
干细胞的自我更新及分化、神经系统功能以及肿瘤发生发展进程中均起着重要作用。因其在消化道肿瘤发生发展
中的重要作用以及作为药物靶点的可行性，本文综述了USP9X在常见的消化系统恶性肿瘤发生发展中作用的研究
进展
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| 关 键 词： | 去泛素化酶 USP9X 信号通路 消化系统肿瘤 综述 |
| 收稿时间： | 2019-01-15 |
| 修稿时间： | 2019-02-28 |
Progress of study on functions of ubiquitin-specific protease 9X in promoting digestive system tumors |
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| WANG Jie-fu,WANG Qian.Progress of study on functions of ubiquitin-specific protease 9X in promoting digestive system tumors[J].Tianjin Medical Journal,2019,47(5):542-548. |
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| Authors: | WANG Jie-fu WANG Qian |
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| Institution: | Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of
Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
△Corresponding Author E-mail: wangqian@tmu.edu.cn |
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| Abstract: | Abstract: Ubiquitin-specific protease 9X (USP9X) is one of the ubiquitin-specific protease(USPs) families of
deubiquitinating enzymes (DUBs). USP9X is DUBs of X chromosome chain, which can play corresponding biological effects
by stabilizing different substrates. USP9X plays an important role in cell signaling transduction, regulation of cell growth and
migration, immune response, self-renewal and differentiation of stem cells, neurological function and carcinogenesis.
Because of its important role in the development of digestive tract tumors and its feasibility as a drug target, this paper
reviews the research progress of USP9X in the occurrence and development of common malignant tumors of digestive system. |
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| Keywords: | deubiquitinase USP9X signaling pathway gastrointestinal cancer review |
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