门冬氨酸洛美沙星注射液治疗急性胃肠炎137例

目的 观察门冬氨酸洛美沙星注射液治疗急性胃肠炎的临床疗效和安全性.方法 选择2006年1月至2011年6月医院门诊收治的274例急性胃肠炎患者,随机分为治疗组和对照组,每组各137例.治疗组给予门冬氨酸洛关沙星注射液0.4 g加入5%葡萄糖注射液250 mL中静脉滴注,对照组静脉滴注庆大霉素注射液24万U,每日1次,疗程均为3 d.结果 治疗组总有效率为94.16%,明显高于对照组69.34%(P<0.05),且临床症状、体征消失时间为显著短于对照组(P<0.05).两组患者在治疗的过程中均未发生明显不艮反应.结论 门冬氨酸洛美沙星注射液治疗急性胃肠炎的临床疗效好、起效快,无明显不良反应,值得临床推广,但18岁以下的患者禁止使用.

Lomefloxacin Aspartate Injection for Treating 137 Cases of Acute Gastroenteritis

Objective To investigate the clinical efficacy and safety of Lomefioxaein Aspartate Injection for treating acute gastroenteritis. Methods Two hundred and seventy four eases of acute gastroenteritis in the outpatient department of our hospital from January 2006 to June 2011 were randomly divided into the treatment group and the control group, 137 cases in each group. The treatment group was treated with Lomefloxacin Aspartate Injection 0.4 g plus 5% Glucose Injection 250 mL by intravenous drip,, once daily, while the con- trol group was treated with Gentamicin Injection 240 000 units by intravenous drip, once daily. The treatment course in the two groups was 3 d. The disappearance time of the clinical symptoms and adverse reactions were observed, and the clinical efficacy was as- sessed. Results The total effective rate was 94. 16% in the treatment group and significantly higher than 69. 34% in the control group with statistical difference between the two groups （P 〈 0. 05）. The disappearance time of clinical symptoms and signs in the treatment group was significantly shorter than that in the control group, the difference had statistical significance （P 〈 0. 05）. Two groups had no apparent adverse reactions in the treatment process. Conclusion The clinical efficacy of Lomefloxacin Aspartate Injection in the treat- ment of acute gastroenteritis is rapid and good without significant adverse reactions, which is worthy of being clinically popularized, but is prohibited in the patients under 18 years old.