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| 健脑丸中五味子甲素含量测定方法的建立 | |
| 引用本文： | 邢军,王红,姚庆强.健脑丸中五味子甲素含量测定方法的建立[J].中国药业,2011,20(5):26-27. |
| 作者姓名： | 邢军 王红 姚庆强 |
| 作者单位： | 1. 山东省医学科学院药物研究所,山东,济南,250062;山东省济宁市药品检验所,山东,济宁,272025 2. 山东省济宁市市中区人民医院,山东,济宁,272100 3. 山东省医学科学院药物研究所,山东,济南,250062 |
| 摘 要： | 目的建立测定健脑丸中五味子甲素含量的高效液相色谱法。方法色谱柱采用Kromasil C18柱(250 mm×4.6 mm,5μm),流动相为乙腈-水(62:38),流速1.0 mL/min,检测波长249nm,柱温35℃。结果五味子甲素进样量在0.1613～1.6128μg范围内与峰面积线性关系良好,r=0.999 995(n=10),平均回收率为99.01%,RSD=0.76%(n=9)。结论高效液相色谱法简便、准确、重复性好,可用于健脑丸的质量控制。 |
| 关 键 词： | 健脑丸 五味子甲素 高效液相色谱法 含量测定 |
Determination of Deoxyschisandrin in Jiannao Pills by HPLC |
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| Xing Jun,Wang Hong,Yao Qingqiang.Determination of Deoxyschisandrin in Jiannao Pills by HPLC[J].China Pharmaceuticals,2011,20(5):26-27. | |
| Authors: | Xing Jun Wang Hong Yao Qingqiang |
| Institution: | 1.Research Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan,Shandong,China 250062;2.Jining Central People′s Hospital, Jining,Shandong,China 272100;3.Jining Municipal Institute for Drug Control,Jining,Shandong,China 272025) |
| Abstract: | Objective To establish a method for determining deoxyschisandrin content in Jiannao Pills.Methods The KromasilTM C18 column（250 mm×4.6 mm,5 μm） was used with the mixture of acetonitrile-H2O（62 ∶38）as the mobile phase and the flow rate of 1.0 mL/min.The detection wavelength was 249 nm and the column temperature was 35 ℃.Results The linear range of deoxyschisandrin was 0.161 3-1.612 8 μg,r=0.999 995（n=10）.The average recovery rate of deoxyschisandrin was 99.01%,RSD=0.76%（n=9）.Conclusion The method is simple,accurate and well reproducible,which is suitable to be used in the quality control of Jiannao Pills. |
| Keywords: | Jiannao Pills Deoxyschisandrin HPLC content determination |
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