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经典药对远志-石菖蒲配伍前后指标成分的变化分析
引用本文:张文娟,郑晓晖,房敏峰,王庆伟,陈焕,李云峰,张琰.经典药对远志-石菖蒲配伍前后指标成分的变化分析[J].中国药业,2009,18(15):6-7.
作者姓名:张文娟  郑晓晖  房敏峰  王庆伟  陈焕  李云峰  张琰
作者单位:1. 第四军医大学唐都医院药剂科,陕西,西安,710038
2. 西北大学生命科学学院,陕西,西安,710069
基金项目:陕西省社会发展攻关项目;项目 
摘    要:目的研究经典药对远志-石菖蒲配伍对单味药材指标成分的影响。方法采用高效液相色谱(HPLC)法测定远志、石菖蒲及远志-石菖蒲药对远志皂苷元和α-细辛醚的含量。色谱柱为ShimadzuVP-ODS柱(150mm×4.6mm,5μm);远志皂苷元的流动相为乙腈-0.05%磷酸水溶液(43:57),检测波长为205nm;α-细辛醚的流动相为乙腈-0.05%磷酸水溶液(52:48),检测波长为257nm。结果远志、远志-石菖蒲中远志皂苷元含量分别为0.392%和0.297%,石菖蒲、远志-石菖蒲中α-细辛醚含量分别为0.0605%和0.0629%。结论远志-石菖蒲配伍后,药对中远志皂苷元的含量显著降低,而α-细辛醚的含量变化不明显。

关 键 词:高效液相色谱法  药对  远志-石菖蒲  远志皂苷元  α-细辛醚

Analysis of Diversify in Matched Pair of Polygala Tenuifolia Willd. and Acorus Tatarinowii Schott by HPLC
Zhang Wenjuan,Zheng Xiaohui,Fang Minfeng,Wang Qingwei,Chen Huan,Li Yunfeng,Zhang Yan.Analysis of Diversify in Matched Pair of Polygala Tenuifolia Willd. and Acorus Tatarinowii Schott by HPLC[J].China Pharmaceuticals,2009,18(15):6-7.
Authors:Zhang Wenjuan  Zheng Xiaohui  Fang Minfeng  Wang Qingwei  Chen Huan  Li Yunfeng  Zhang Yan
Institution:1. Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi' an, Shaanxi, China 710038; 2. College of Life Science, Northwest Uiniversity, Xi' an, Shaanxi, China 710069)
Abstract:Objective To research the compatibility regularity of the matched pair of Polygala tenuifolia Willd. and Acorus tatarinowii Schott. Methods The mobile phase of senegenin was acetonitrile- 0. 05% phosphoric acid(43 : 57), the detective wavelength was 205 nm; the mobile phase of α-asaricin was acetonitrile-0. 05% phosphoric acid(52:48), the detective wavelength was 257 nm. The flow rate was about 1 mL/min, and the Shimadzu VP- ODS (150 mm × 4. 6 mm, 5 μm) column was used. Results The contents of senegenin in Polygala tenuifolia Willd. and the matched pair of Polygala tenuifolia Willd. and Acorus tatarinowii Schott were 0. 392% and 0. 297% respectively; the contents of α- asaricin in Acorus tatarinowii Schott and the matched pair of Polygala tenuifolia Willd. and Acorus tatarinowii Schott were 0. 060 5% and 0. 062 9% respectively. Conclusion After the match of Polygala tenuifolia Willd. and Acorus tatarinowii Schott, the content of matched pair was decreased obviously, but there was not obviously change of α- asaricin.
Keywords:HPLC  matched pair  Polygala tenuifolia Willd  and Acorus tatarinowii Schott  senegenin  α - asaricin
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