| 归脾丸（浓缩丸）质量标准研究 |
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| 引用本文： | 沙娟,赵长振,施爱红,王法琴,叶华,王瑞娟.归脾丸（浓缩丸）质量标准研究[J].中国药业,2007,16(5):29-30. |
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| 作者姓名： | 沙娟 赵长振 施爱红 王法琴 叶华 王瑞娟 |
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| 作者单位： | 苏州长甲药业有限公司,江苏,苏州,215011 |
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| 摘 要： | 目的建立归脾丸（浓缩丸）的质量标准。方法用薄层色谱法（TLC法）对归脾丸（浓缩丸）中黄芪甲苷、远志、木香进行定性鉴别；用高效液相色谱法（HPLC）测定归脾丸中甘草酸的含量，色谱柱为C18柱（250mm×4．6mm，5μm），流动相为甲醇-水-乙酸（65：30：5）．流速为1．0mL／min，柱温40℃，检测波长250nm。结果TLC法色谱斑点清晰，空白无干扰；HPLC法的甘草酸平均回收率为100．18％。RSD为1.22％。结论方法准确，重现性好，可用于归脾丸（浓缩丸）的质量控制。
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| 关 键 词： | 归脾丸 黄芪 远志 木香 甘草酸 薄层色谱法 高效液相色谱法 |
| 文章编号： | 1006-4931（2007）05-0029-02 |
| 收稿时间： | 2006-07-21 |
| 修稿时间： | 2006-10-16 |
Quality Standard for Guipi Pills (Concentrated Pills) |
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| Sha Juan,Zhao Changzhen,Shi Aihong,Wang Faqin,Ye Hua,Wang Ruijuan.Quality Standard for Guipi Pills (Concentrated Pills)[J].China Pharmaceuticals,2007,16(5):29-30. |
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| Authors: | Sha Juan Zhao Changzhen Shi Aihong Wang Faqin Ye Hua Wang Ruijuan |
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| Institution: | Sha Juan, Zhao Changzhcn, Shi Aihong, Wang Faqin, Ye Hun, Wang Ruijuan ( Suzhou Changjia Pharmaceutical Co., Ltd., Suzhou, Jiangsu, China 215011) |
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| Abstract: | Objective To establish the quality standard of Guipi pills （concentrated pills）. Methods Radix Astragali, Radix Polygalae, Radix Aucklandiae were identified by TLC,glycyrrhizic acid was determined by HPLC. HPLC column was C,s （250 mm ×4.6 mm, 5 μm）.The mobile phase was methanol-water-acetic acid （65：30：5） and the flow rate was 1.0 mL/min. The column tempreture was 40℃ and the detection wavelength was at 250 nm. Results Radix Astragali, Radix Polygalae, Radix Aucklandiae were distinguished by TLC,the mean recovery rate of glycyrrhizic acid was 100. 18%, RSD was 1.22%. Conclusion The method is accurate and reproducible. It can be used for quality control of Guipi pills （concentrated pills）. |
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| Keywords: | Guipi pills Radix Astragali Radix Polygalae Radix Aucklandiae glycyrrhizic acid TLC HPLC |
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