血管内皮生长因子及其靶向治疗

血管新生在胚胎发育、器官形成、伤口愈合及其他正常生理过程中具有非常重要的作用.此外,在一些病理过程中也涉及血管生成,这些病理过程包括肿瘤的生长与转移、糖尿病引起的视网膜病变、年龄相关性黄斑变性、类风湿关节炎以及银屑病等.研究表明血管内皮生长因子(vascular endothelial growth factor,VEGF)在正常生理和病理性血管形成中起着非常重要的作用.因此,VEGF靶向治疗已成为肿瘤及相关疾病治疗的重要策略.

Vascular endothelial growth factor and its targeted therapy

Angiogenesis is very important for embryogenesis, organ development, wound healing, and other normal physiological processes. In addition, angiogenesis is also implicated in some pathological processes, such as tumor growth and metastasis, diabetic retinopathy, age-related macular degeneration,rheumatoid arthritis, and psoriasis. Research shows that VEGF plays an important role in physiological and pathological angiogenesis. Thus, VEGF-targeted therapy has become an important strategy for the treatment of cancer and related diseases.