硫酸镁对急性脑梗死患者NIHSS评分及NSE的影响

目的观察硫酸镁治疗急性脑梗死的疗效,分析镁离子对急性脑梗死患者美国国立卫生研究院卒中量表评分(NIHSS)及神经元特异性烯醇化酶(NSE)的影响。方法选择2016年3月-2019年9月在广东省潮州市人民医院住院治疗的急性脑梗死患者100例,根据掷币法随机分为观察组50例和对照组50例。对照组采用综合治疗,观察组在对照组治疗基础上联合硫酸镁治疗。比较2组患者治疗前后NIHSS评分、NSE水平及临床疗效和不良反应发生情况。结果2组治疗后NIHSS评分均低于治疗前(P<0.05),且观察组NIHSS评分低于对照组(P<0.05)。治疗第5天,2组NSE均升高(P<0.05),但观察组低于对照组(P<0.05);治疗第10天,2组NSE均低于治疗前和治疗第5天(P<0.05),且观察组低于对照组(P<0.05)。观察组总有效率为88.0%高于对照组的70.0%(P<0.05)。2组均未见严重不良反应发生。结论硫酸镁可为急性脑梗死的辅助治疗提供新的方法。

Effect of magnesium sulfate on NIHSS score and NSE in patients with acute cerebral infarction

Objective To observe the efficacy of magnesium sulfate in treating acute cerebral infarction,and to analyze the effect of magnesium ion on the NIHSS score and NSE of patients with acute cerebral infarction.Methods100 patients with acute cerebral infarction hospitalized in Chaozhou People’s Hospital,Guangdong Province from March2016 to September 2019 were selected,and they were randomly divided into observation group(50 cases)and control group(50 cases).The control group received comprehensive treatment,while the observation group was additionally treated with magnesium sulfate on the basis of the control group.The score of NIHSS,the level of NSE,clinical efficacy and adverse reactions of the two groups were compared before and after treatment.Results The NIHSS scores of the two groups after treatment were lower than before treatment(P<0.05),and the NIHSS scores of the observation group were lower than the control group(P<0.05).On the 5 th day of treatment,the level of NSE increased in both groups(P<0.05),but the observation group was lower than the control group(P<0.05);On the 10 th day of treatment,the level of NSE in both groups was lower than before and 5 th day(P<0.05),and the observation group was lower than the control group(P<0.05).The total effective rate in the observation group(88.0%)was higher than that in the control group(70.0%)(P<0.05).No serious adverse reactions occurred in either group.Conclusion Magnesium sulfate can provide a new method for the adjuvant treatment of acute cerebral infarction.