| 低剂量氯氮平合并阿立哌唑对精神分裂症患者体质量及糖脂代谢的影响 |
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| 引用本文： | 徐玉英.低剂量氯氮平合并阿立哌唑对精神分裂症患者体质量及糖脂代谢的影响[J].临床合理用药杂志,2013(36):126-127. |
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| 作者姓名： | 徐玉英 |
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| 作者单位： | 江苏省张家港市康乐医院精神科,215600 |
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| 摘 要： | 目的探讨较低剂量氯氮平联合阿立哌唑对精神分裂症患者体质量及糖脂代谢的影响，进一步指导临床治疗。方法选取我院2010年1月—2012年1月收治的精神分裂症患者92例，随机分为观察组和对照组，对观察组采用低剂量氯氮平联合阿立哌唑进行治疗，对照组采用单纯的氯氮平进行治疗。对两组的治疗效果进行对比。结果两组患者治疗后较治疗前阳性与阴性症状量表（PANSS）评分降低，差异有统计学意义（P〈0．05）；治疗后，观察组体质量和糖脂代谢水平变化幅度较对照组小，差异有统计学意义（P〈0．05）。结论较低剂量氯氮平联合阿立哌唑治疗精神分裂症较单纯使用氯氮平进行治疗的临床效果更佳，对患者体质量和糖脂代谢的影响较小，不良反应少，值得在临床推广应用。
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| 关 键 词： | 氯氮平 阿立哌唑 精神分裂症 体重 糖脂代谢 治疗结果 |
The Effect of Small Dose of Clozapine Combined Aripiprazole on Weight and Glucolipid Metabolism for Psychopaths |
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| Institution: | XU Yu - ying. Psychiatric hospital Kangle , Zhangiiagang 215600, China |
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| Abstract: | Objective To discuss the effect of small dose of clozapine combined aripiprazole on weight and glucolipid metabolism. Methods Choosed 92 psychopaths from Jan. 2010 to Jan. 2012 to divide into study group and controlled group. The study group were treated with small dose of clozapine combined aripiprazole, controlled group were treated with c｜ozapine on- ly. Compared the effect of these two groups. Results The effect of these two groups and adverse effects were no difference. Conclusion Treating psychopaths with small dose of clozapine combined aripiprazole on weight and glucolipid metabolism has good effect to extend in clinic. |
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| Keywords: | Clozapine Aripiprazole Schizophrenia Body weight Glucose and lipid metabolism Treatment outcome |
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