| 荨麻青霉对莪术醇的微生物转化 |
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| 引用本文： | 孙敏鸽,康宁,段文娟,陈丽霞,曲戈霞,邱峰.荨麻青霉对莪术醇的微生物转化[J].沈阳药科大学学报,2007,24(8):512-514. |
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| 作者姓名： | 孙敏鸽 康宁 段文娟 陈丽霞 曲戈霞 邱峰 |
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| 作者单位： | 1. 沈阳药科大学,中药学院,辽宁,沈阳,110016
2. 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的使用荨麻青霉(IFFI 04015,Penicillium urticae)对莪术醇进行微生物转化研究。方法采用一级发酵培养的方法对菌体进行发酵培养,并在此发酵培养液中对莪术醇进行微生物转化,通过硅胶柱色谱和制备型HPLC等方法从其发酵培养液中分离得到2个转化产物,利用光谱学方法对其进行结构鉴定。结果2个化合物的结构分别鉴定为3-α-羟基莪术醇(1)和11-R-12-羟基莪术醇(2)。结论化合物1为未见文献报道的新化合物,化合物2为首次通过该真菌对莪术醇生物转化得到。
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| 关 键 词： | 微生物转化 莪术醇 荨麻青霉 |
| 文章编号： | 1006-2858（2007）08-0512-03 |
| 修稿时间： | 2007-03-09 |
Biotransformation of curcumol by Penicillium urticae |
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| SUN Min-ge,KANG Ning,DUAN Wen-juan,CHEN Li-xia,QU Ge-xia,QIU Feng.Biotransformation of curcumol by Penicillium urticae[J].Journal of Shenyang Pharmaceutical University,2007,24(8):512-514. |
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| Authors: | SUN Min-ge KANG Ning DUAN Wen-juan CHEN Li-xia QU Ge-xia QIU Feng |
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| Institution: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective To study the biotransformation of curcumol by Penicillium urticae.Methods The method of one-step fermentation was used to study the biotransformation of curcumol.Two metabolites were isolated from the EtOAc extract of the broth by column chromatography on silica gel and preparative HPLC and identified by spectral data.Results Their structures were elucidated as 3α-hydroxycurcumol(2)and 11R-12-hydroxycurcumol(3).Conclusions Compound 2 is a new compound,and compound 3 is obtained through biotransformation of curcumol by Penicillium urticae for the first time. |
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| Keywords: | biotransformation curcumol Penicillium urticae |
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