马齿苋的化学成分

目的研究马齿苋的化学成分。方法利用硅胶、Sephadex-LH-20、ODS等柱色谱方法进行分离纯化,根据理化性质及波谱数据(1H-NMR、13C-NMR)进行结构鉴定。结果从马齿苋中分离得到8个化合物,分别鉴定为2,5-二羧基吡咯(1 H-pyrrole-2,5-dicarboxylic acid,1)、5-羟基-2-羧基吡啶(5-hydroxy-2-pyridinecarboxylic acid,2)、马齿苋酰胺B(oleracein B,3)、3,4-二羟基苯甲酸(3,4-di-hydroxybenzoic acid,4)、木栓酮(friedelin,5)、4α-甲基-3β-羟基-木栓烷(4α-methyl-3β-hydroxyl-friedelan,6)、羽扇豆醇(lupeol,7)、环(亮氨酸-苯丙氨酸)(cyclo(L-leucinyl-L-tyrosinyl),8)。结论化合物1、2、8首次从马齿苋属中分离得到。

Chemical constituents from Portulaca oleracea L.

Objective To separate and identify the chemical constituents of the extract from the Portulaca oleracea L. Methods The compounds were separated by repeated silica gel SephadexLH-20 and ODS. The structures of these isolated compounds were identified on the basis of their spectral data （¹H-NMR,¹³C-NMR）and chemical properties. Results Eight compounds were isolated from Portulaca oleracea L. and their structures were identified as 1H-pyrrole-2,5-dicarboxylic acid（1）, 5-hydroxy-2-pyridinecarboxylic acid（2）,oleracein B（3）, 3,4-dihydroxybenzoic acid(4), friedelin(5), 4α-methyl-3β-hydroxylfriedelan(6), lupeol(7) and cyclo（L-leucinyl-L-tyrosinyl）(8). Conclusions Compounds 1, 2 and 8 are isolated from Portulaca for the first time.