延胡索的化学成分

目的分离并鉴定延胡索的化学成分。方法采用硅胶柱色谱、氧化铝柱色谱和重结晶等多种分离方法对延胡索的体积分数为85%的乙醇溶液提取物进行分离,并通过NMR、ESI-MS和TLC等多种方法对分离得到的化学成分进行结构鉴定。结果分离得到13个化合物,分别鉴定为四氢紫堇萨明(tetrahydrocorysamine,1)、四氢黄连碱(tetrahydrocoptisine,2)、紫堇碱(corydaline,3)、四氢巴马亭(tetrahydropal matine,4)、去氢紫堇碱(dehydrocorydaline,5)、oxoglaucine(6)、降氧化北美黄连次碱(noroxyhydrastinine,7)、四氢小檗碱(tetrahydroberberine,8)、山嵛酸(behenic acid,9)、β谷甾醇(βsitosterol,10)、胡萝卜苷(daucosterol,11)、香草酸(vanillic acid,12)、对羟基苯甲酸(phy-droxybenzoic acid,13)。结论其中化合物9、12、13为首次从该属植物中分离得到,化合物6、7、10、11为首次从该植物中分离得到。

Chemical constituents from the bulb of Corydalis yanhusuo W.T.Wang

Objective To isolate the chemical constituents and elucidate their structures from the bulb of Corydalis yanhusuo W.T.Wang. Methods The compounds were isolated by chromatography on silica gel, Al2O3 column and recrystallization methods. NMR,TLC and ESI-MS were employed for the structure identification. Results Thirteen compounds were obtained and elucidated as: tetrahydrocorysamine(1), tetrahydrocoptisine(2), corydaline(3), tetrahydropalmatine(4), dehydrocorydali-ne(5), oxoglaucine(6), noroxyhydrastinine(7), tetrahydroberberine(8), behenicacid(9), β-sitosterol(10), dau-costerol(11), vanillicacid(12), p-hydroxybenzoic acid(13), respectively. Conclusions Among these compounds, 9, 12, and 13 are obtained from the Corydalis genus for the first time; 6, 7, 10 and 11 are obtained from this plant for the first time.