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黄花蒿幼嫩叶的化学成分
引用本文:陈靖,周玉波,张欣,黄莉,孙微,王金辉.黄花蒿幼嫩叶的化学成分[J].沈阳药科大学学报,2008,25(11):866-870.
作者姓名:陈靖  周玉波  张欣  黄莉  孙微  王金辉
作者单位:沈阳药科大学中药学院,山东日照职业技术学院
摘    要:目的研究黄花蒿(Artemisia annuaL.)全草的化学成分。方法用硅胶、聚酰胺和SephadexLH-20柱色谱分离化合物,根据理化性质和波谱数据鉴定其结构。结果从黄花蒿全草的乙醇提取物中分离得到13个化合物,分别鉴定为:青蒿素(artemisinin,1)、青蒿乙素(arteannuin B,2)、3α-羟基-1-去氧青蒿素(3α-hydroxy-1-deoxyartemisinin,3)、青蒿酸(artemisinic acid,4)、artemetin(5)、猫眼草黄素(chrysosplenetin,6)、quercetagetin-3,7,3′,4′-tetramethyl ether(7)、猫眼草酚(chrysosplenol D,8)、水杨酸(salicylic acid,9)、domesticoside(10)、东莨菪苷(scopolin,11)、β-谷甾醇(β-sitosterol,12)、胡萝卜苷(daucostrol,13)。结论化合物1-4为同一类化合物,属倍半萜类,化合物5-8为具有多甲氧基取代的黄酮类化合物,化合物10为首次从菊科植物中分离得到。

关 键 词:黄花蒿  化学成分  倍半萜  黄酮
收稿时间:2008-1-18

Chemical constituents of Artemisia annua L.
CHEN Jing,ZHOU Yu-Bo,ZHANG Xin,HUANG Li,SUN Wei,WANG Jin-hui.Chemical constituents of Artemisia annua L.[J].Journal of Shenyang Pharmaceutical University,2008,25(11):866-870.
Authors:CHEN Jing  ZHOU Yu-Bo  ZHANG Xin  HUANG Li  SUN Wei  WANG Jin-hui
Institution:(1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. Ri Zhao Polytechnic, Shan Dong Ri Zhao 276826)
Abstract:Objective To study chemical constituents from the herbs of Artemisia annua. Methods Compounds were isolated and purified by column chromatography over Sephadax LH - 20 and silica gel column. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data. Results Thirteen compounds were isolated, purified, and identified as: artemisinin (1), arteannuin B (2), 3α-hydroxy-1-deoxyartemisinin (3), artemisinic acid (4), artemetin (5), chrysosplenetin (6), quercetagetin-3, 7, 3’,4’-tetramethyl ether (7), chrysosplenol D (5, 3’, 4’-trihydroxy-3, 6, 7-trimethoxyflavone, 8), salicylic acid (9),domesticoside (2-O-β-D-glucopyranosyl-4-O-methyl phloracetophenone, 10), scopolin (11), β-sitosterol (12), daucostrol (13). Conclusion Compounds 1-4 belong to biosynthetic related sesquiterpenoid, and compound 10 is isolated from the Compositae family for the first time.
Keywords:Artemisia annua L    chemical constituents  sesquiterpenoid  flavone
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