药物载体空白脂质体前体的制备及性质的研究

以蛋黄卵磷脂、胆固醇为膜材，加入适量的高分子表面活性剂，选择合适的支持剂，采用冷冻干燥法制备了空白脂质体前体，并用它作为药物载体，将药物溶液分散在载体中，制成药物脂质体．研究了空白脂质体前体的再分散性及物理稳定性．空白脂质体前体再分散性良好，平均粒径为０．７５μｍ，粒径分布比较集中，在室温下贮存７个月、９个月后再分散其平均粒径分别为０８１μｍ、０８４μｍ，对５ Ｆｕ的包裹率也没有发生显著改变。用５ Ｆｕ，阿霉素（ＡＤＭ）等为模型药物，考察了影响药物脂质体包裹率的因素，并将最优条件固定．研究结果表明：空白脂质体水相的ｐＨ值、离子强度、再分散药物溶液的浓度（即药物与磷脂的重量比）对药物包裹率有显著影响．

Studies on the Preparation and Characteristics of Empty Proliposomes as a Drug Carrier

The empty proliposomes were prepared by the freezedried method composed of EPC,Chol and surfactant in the presence of a proper cryoprotectant.We used this empty proliposomes as a drug carrier to entrap hydrophilic drugs and the effects of trap efficiency were investigated as well.The results showed that the trap efficiency was influenced significantly by pH,ion strength of the buffer solution and by the weight ratio of EPC to drug.The mean particle size of the proliposomes after redispersion was 075 m and 081 m,084 m respectively after storing for 7 months and 9 months at room temperature.The trap efficiency to 5Fu was not changed either after storing.The physical stability of this drug carrier was good.