石见穿化学成分的分离与鉴定

目的寻找石见穿(Salvia chinensis Benth.)的活性成分,阐明其药效物质基础。方法采用硅胶柱色谱、凝胶柱色谱、十八烷基键合硅胶柱色谱分离;根据波谱数据分析鉴定化合物的结构。结果从石见穿中分离鉴定了9个化合物,分别为3-吲哚甲醛(indolyl-3-carbaldehyde,1)、芥子醛(sinapaldehyde,2)、松柏醛(coniferyl aldehyde,3)、丁香醛(syringaldehyde,4)、对羟基苯甲醛(p-hydroxybenzaldehyde,5)、香草醛(vanillin,6)、5-羟甲基糠醛(5-hydroxymethyl furaldehyde,7)、β-谷甾醇(β-sitosterol,8)、胡萝卜苷(daucosterol,9)。结论化合物1为首次从鼠尾草属植物中分离得到,化合物2~5、7为首次从石见穿中分离得到。

Isolation and identification of chemical constituents of theaerial parts of Salvia chinensis B.

Abstract: Objective To study the chemical constituents of the aerial parts of Salvia chinensis Benth. Methods The constituents were isolated by silica gel, ODS, Sephadex LH-20 column chromatography and the spectroscopic analysis methods were employed for the structural identification. Results Nine compounds were obtained and their structures were identified as indolyl-3-carbaldehyde (1), sinapaldehyde (2), coniferyl aldehyde (3), syringaldehyde (4), p-hydroxybenzaldehyde (5), vanillin (6), 5-hydroxymethyl furaldehyde (7), β-sitosterol (8) and daucosterol (9). Conclusions Compound 1 is isolated from the genus Salvia for the first time. Compounds 2-5 and 7 are isolated from Salvia chinensis for the first time.