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黄芩苷的物化常数测定
引用本文:王弘,陈济民,张清民.黄芩苷的物化常数测定[J].沈阳药科大学学报,2000,17(2).
作者姓名:王弘  陈济民  张清民
作者单位:沈阳药科大学药学系,沈阳,110015
摘    要:采用紫外分光光度法测定了黄芩苷在不同溶媒中的溶解度、油 /水分配系数、pKa值 .结果表明 :黄芩苷在甲醇、乙醇中溶解度分别为 15 6 9μg/mL和 145 8μg/mL ,较其它溶媒高 ;在酸性条件下的油 /水分配系数较大 ,pKa值为 5 .0 47.

关 键 词:黄芩苷  溶解度  油/水分配系数  pKa值

Determination of the Physical Chemistry Constants of Baicalin
Wang Hong,Chen Jimin,Zhang Qingmin.Determination of the Physical Chemistry Constants of Baicalin[J].Journal of Shenyang Pharmaceutical University,2000,17(2).
Authors:Wang Hong  Chen Jimin  Zhang Qingmin
Abstract:The solubility in different solvents, the oil/water detached coefficient and pKa value of baicalin were determined by UV spectrophotometry for the study of its absorption in vivo. The results showed that the higher solubility values of baicalin were 1 569 μg/mL and 1 458 μg/mL in methanol and ethanol, while the oil/water detached coefficient was higher in acid solvent,the pKa value of baicalin was 5.047.
Keywords:baicalin  solubility  oil/water detached coefficient  pKa value  
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