| Effects of Ro 31-8220 on smooth muscle cell proliferation induced by fibrinogen degradation products |
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| 引用本文： | 周斌,张俊平,胡振林,陶学斌,钱定华.Effects of Ro 31-8220 on smooth muscle cell proliferation induced by fibrinogen degradation products[J].中国药理学报(英文版),1997(5). |
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| 作者姓名： | 周斌 张俊平 胡振林 陶学斌 钱定华 |
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| 作者单位： | 第二军医大学药学院中西药研究室 |
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| 摘 要： | 目的：研究纤维蛋白原降解产物的致有丝分裂原活性及一种新型ＰＫＣ抑制剂Ｒｏ３１８２２０（Ｒｏ）的作用．方法：大鼠主动脉平滑肌细胞增殖采用结晶紫染色法测定．结果：纤维蛋白原降解产物促进大鼠主动脉平滑肌细胞的增殖，Ｒｏ（００１－１μｍｏｌ·Ｌ－１）剂量依赖地抑制增殖．结论：Ｒｏ抑制纤维蛋白原降解产物诱导的平滑肌细胞的增殖．
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| 关 键 词： | Ro31-8220 纤维蛋白原降解产物 蛋白激酶C 血管平滑肌 培养的细胞 胸主动脉 |
Effects of Ro 31 8220 on smooth muscle cell proliferation induced by fibrinogen degradation products |
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| ZHOU Bin,ZHANG Jun Ping,HU Zhen Lin,TAO Xue Bin,QIAN Ding Hua.Effects of Ro 31 8220 on smooth muscle cell proliferation induced by fibrinogen degradation products[J].Acta Pharmacologica Sinica,1997(5). |
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| Authors: | ZHOU Bin ZHANG Jun Ping HU Zhen Lin TAO Xue Bin QIAN Ding Hua |
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| Institution: | ZHOU Bin,ZHANG Jun Ping,HU Zhen Lin,TAO Xue Bin,QIAN Ding Hua 2 |
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| Abstract: | |
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| Keywords: | Ro 31 8220 fibrin fibrinogen degradation products protein kinase C vascular smooth muscle cultured cells thoracic aortam |
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