阿芙唑嗪及多沙唑嗪十二指肠给药对猫尿道压的选择性作用(英文)

目的:观察不同给药途径对阿芙唑嗪(Alf)和多沙唑嗪(Dox)降尿道压的选择性作用,方法:电刺激麻醉猫腹下神经以升高尿道压。比较十二指肠和静脉两种途径给药时,Alf和Dox降低平均动脉血压(MBP)及尿道压(UP)的作用,结果:相同电刺激条件下(10 Hz,25 V),Alf肠道给药与静脉给药时ED_(20)(BP))/ED_(50)(UP))比值为10.9:4.3;Dox两种给药途径的比值为3.1:2.1,Alf十二指肠给药降尿道压作用的选择性优于静脉给药,Dox两种给药途径的作用无显著性差异,结论:Alf胃肠道给药时,选择性降低电刺激诱发的尿道压升高,而Dox无此特点,Alf对尿道的选择性作用与药物生物利用度和生物转化的种属差异无关。

Selective effects of alfuzosin and doxazosin with intraduodenal administration on urethral pressure of cats

AIM: To observe the selective effects of alfuzosin (Alf) and doxazosin.(Dox) on the urethral pressure by different administration routes. METHODS: The urethral pressure of the anesthetized cat was increased by electric stimulation of the hypogastric nerve. The different effects of Alf or Dox on the arterial blood pressure and urethral pressure between intraduodenal administration (id) and intravenous infusion (iv) were compared. RESULTS: When the hypogastric nerve was stimulated by electric stimulation (10 Hz, 25 V), the ratios of ED20(Bp)/ED50(UP) id to ED20(BP)/ED50(UP) iv were 10.9:4.3 for Alf, and 3.1:2.1 for Dox. The reduction in urethral pressure induced by id Alf was greater than that by iv Alf. Dox did not show any difference in its effects by 2 administration routes. CONCLUSION: Intraduodenal administration of Alf, but not Dox, selectively decreased the urethral pressure elevated by electric stimulation. The uroselectivity of id Alf was not due to the species difference in its bioavailability and biotransformation.