| 硒与认知功能 |
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| 引用本文： | 余海立,陈智仙,张彦,朱杰,张双庆. 硒与认知功能[J]. 中国药事, 2019, 33(4): 385-390 |
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| 作者姓名： | 余海立 陈智仙 张彦 朱杰 张双庆 |
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| 作者单位： | 酵母功能湖北省重点实验室, 宜昌 443003,酵母功能湖北省重点实验室, 宜昌 443003,酵母功能湖北省重点实验室, 宜昌 443003,酵母功能湖北省重点实验室, 宜昌 443003,中国疾病预防控制中心营养与健康所, 北京 100050 |
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| 基金项目： | 湖北省自然科学基金（编号2017CFB572；编号2018CFB612） |
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| 摘 要： | 目的：探索硒在认知功能中的作用，硒化合物作为认知功能损伤防治药物的可能性。方法：查阅硒与认知功能的动物试验和人群研究文献，总结硒在认知功能中的作用。结果与结论：硒对维持中枢神经系统的生物学功能具有重要作用，认知功能下降与硒水平下降有关，硒化合物具有成为认知功能损伤防治药物的潜力。
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| 关 键 词： | 硒 氧化应激 认知功能 硒蛋白 |
| 收稿时间： | 2018-12-11 |
On Selenium and Cognitive Function |
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| Yu Haili,Chen Zhixian,Zhang Yan,Zhu Jie and Zhang Shuangqing. On Selenium and Cognitive Function[J]. Chinese Pharmaceutical Affairs, 2019, 33(4): 385-390 |
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| Authors: | Yu Haili Chen Zhixian Zhang Yan Zhu Jie Zhang Shuangqing |
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| Affiliation: | Hubei Provincial Key Laboratory of Yeast Function, Yichang 443003, China,Hubei Provincial Key Laboratory of Yeast Function, Yichang 443003, China,Hubei Provincial Key Laboratory of Yeast Function, Yichang 443003, China,Hubei Provincial Key Laboratory of Yeast Function, Yichang 443003, China and National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China |
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| Abstract: | Objective: To explore the role of selenium in cognitive function and the possibility of selenium compounds as drugs to prevent and cure cognitive impairments. Methods: The literature on experiments and population study on selenium and cognitive function were searched and reviewed. The role of selenium in cognitive was summarized. Results and Conclusion: Selenium plays an important role in maintaining the biological function of the central nervous system. Cognitive decline is related to the decrease of selenium level and selenium compound has the potential to be a therapeutic drug for cognitive impairment. |
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| Keywords: | selenium oxidative stress cognitive function selenoprotein |
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