抗菌药物规范化管理对我院美罗培南应用的影响

目的：探讨抗菌药物规范化管理对医院美罗培南应用的影响。方法：以本院2016年8月-2016年12月期间90例抗菌药物应用患者作为对照组，以本院2017年1月-2017年5月期间90例抗菌药物应用患者作为研究组，自2017年1月开始加强特殊抗菌药美罗培南的规范化管理，比较两组用药合理性、有效性与药物副作用的差异。结果：研究组美罗培南平均用药时间（4.81±1.03）d，明显短于对照组（6.96±1.62）d，美罗培南应用率（27.78%）明显低于对照组（50.00%），两组比较具有显著性差异（P<0.05）。研究组用药不合理率16.67%（15/90），明显低于对照组的50.00%（45/90），两组比较具有显著性差异（P<0.05）。研究组治疗总有效率96.67%，明显高于对照组77.78%，两组比较也具有显著性差异（P<0.05），但两组药物副作用发生率比较（2.22% vs 4.44%）不具有显著性差异（P>0.05）。结论：抗菌药物规范化管理指导医院美罗培南的临床合理应用，值得临床进一步推广应用。

Effect of Standardized Management of Antibiotics on Application of Meropenem in Our Hospital

Objective: To discuss the effect of standardized management of antibiotics on the application of Meropenem in hospitals. Methods: 90 cases of patients administrated antibiotics from August 2016 to December 2016 in our hospital were used as control group, 90 cases of patients administrated antibiotics from January 2017 to May 2017 in our hospital were used as study group. The standardized management of the special antibiotics, Meropenem had been strengthened since January 2017. The differences of rationality, effectiveness and adverse drug reaction of the two groups were compared. Results: Average duration (4.81±1.03)d of Meropenem in the study group was significantly shorter than that (6.96±1.62)d of the control group. The application rate of Meropenem (27.78%) in the study group was significantly lower than that in the control group (50.00%), showing statistically significant difference (P<0.05). The irrational rate of the study group was 16.67% (15/90), significantly lower than that of the control group 50.00% (45/90), showing statistically significant difference (P < 0.05). The total effective rate of the study group (96.67%) was significantly higher than that of the control group which was 77.78%, showing statistically significant difference (P<0.05). However, the rate of the adverse drug reaction between the two groups (2.22% vs 4.44%) did not show statistically significant difference (P>0.05). Conclusion: The standardized management of antibiotics to guide the rational application of Meropenem in hospitals is worthy of clinical popularization and application.