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开展降钙素原监测指导临床合理使用抗菌药物
引用本文:何宣蓉,;李冠锋,;阿古再,;魏锦绣,;李建娥,;杨珍珍,;徐春凤.开展降钙素原监测指导临床合理使用抗菌药物[J].中国药事,2014(9):1029-1033.
作者姓名:何宣蓉  ;李冠锋  ;阿古再  ;魏锦绣  ;李建娥  ;杨珍珍  ;徐春凤
作者单位:[1]新疆心脑血管病医院,乌鲁木齐841100; [2]乌鲁木齐市第一人民医院,乌鲁木齐841100;
摘    要:目的:分析新疆心脑血管病医院(简称“我院”)降钙素原(PCT)监测现状,研究 PCT 监测流程,指导临床抗菌药物合理应用。方法实时监测我院2013-04-18-2013-10-18住院患者血清 PCT 值,并跟踪每一位检测PCT患者的抗菌药物使用情况。结果共对262人(同一患者转科只计一人)进行了PCT监测,其中89.4%的患者只检测了1次,10.6%的患者作了2次或2次以上检测;血清PCT〈0.1 ng·mL-1的患者有49.4%使用了抗菌药物,PCT≥0.1 ng·mL-1的患者有94.9%使用了抗菌药物;外科手术患者PCT监测率为19.25%,使用抗菌药物的占99.2%;心内科介入手术及非手术患者共监测222次,其中使用抗菌药物的占78.4%。结论我院PCT送检次数、送检时间不科学,缺乏连续检测,缺少对 PCT 值的动态观察,未体现出PCT指导临床抗菌药物合理使用的作用。

关 键 词:生物标记物监测  降钙素原  PCT监测流程  抗菌药物  临床合理用药

Monitoring of Procalcitonin to Guide Clinical Rational Use of Antibacterial Drugs
Institution:He Xuanrong, Li Guanfeng, A Guzai, Wei Jingxiu, Li Jiane, Yang Zhenzhen, Xu Chunfeng (Xiniiang Hospital of Cardio-cerebrovascular Diseases, Urumqi 841100; 1The First People's Hospital of Urumqi)
Abstract:Objective To analyze the status of monitoring of procalcitonin (PCT)in our hospital (Xinjiang Hospital of Cardio-cerebrovascular Diseases ), study the PCT monitoring process of procalcitonin and guide clinical rational use of antibacterial drugs. Methods Real time monitoring was conducted for serum PCT values of hospitalized patients from April 18 to October 18, 2013, and antibacterial drug use of each patient with PCT detected was tracked.Results A total of 262 people (the same patient who was referred to other departments was calculated as one)received PCT monitoring, 89.4% of the patients were tested only 1 time,10.6% of the patients received PCT test for 2 times or more.Among patients whose serum PCT〈0.1 ng · mL-1 ,49.4% of them used antibacterial drugs;among patients with PCT≥0.1 ng·mL-1 ,94.9% of them used antibacterial drugs.The PCT monitoring rate in surgical patients was 19.25%,99.2% of whom used antibacterial drugs.The PCT monitoring was performed 222 times for patients both with invasive surgery and without surgery in the department of cardiology,among whom 78.4% patients who used antibacterial drugs.Conclusion Delivering frequency and delivering time of PCT samples were unscientific in our hospital with lack of continuous testing and dynamic observation of PCT values, which made PCT inefficient on guiding clinical rational use of antibacterial drugs.
Keywords:biomarker monitoring  procalcitonin (PCT)  PCT monitoring process  antibacterialdrugs  clinical rational drug use
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