| Box-Behnken效应面法优化牛蒡苷pH敏感脂质体处方 |
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| 引用本文： | 武鑫朋,孙李妍,慕宏杰,杨绍梅,魏俊花,周绣棣,陈大全.Box-Behnken效应面法优化牛蒡苷pH敏感脂质体处方[J].齐鲁药事,2011,30(11):625-628. |
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| 作者姓名： | 武鑫朋 孙李妍 慕宏杰 杨绍梅 魏俊花 周绣棣 陈大全 |
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| 作者单位： | 1. 烟台大学药学院,山东烟台,264005
2. 烟台大学药学院,山东烟台264005;烟台山医院,山东烟台264001 |
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| 摘 要： | 目的以牛蒡苷(arctiin,AC)为模拟药,通过Box-Behnken效应面法优化制备AC-pH敏感脂质体。方法采用薄膜分散法制备脂质体,分别以磷脂-胆固醇比(X1)、磷脂-药质量比(X2)、pH敏感材料含量(X3)为考察对象,以包封率(Y1)、载药量(Y2)和粒径(Y3)为评价指标,利用三因素三水平Box-Behnken效应面设计法筛选牛蒡苷pH敏感脂质体的最佳处方;并考察该制剂的稳定性。结果牛蒡苷pH敏感脂质体的平均包封率为(93.25±1.5)%;平均载药量(94.10±1.8)%;平均粒径为(208.55±2.8)nm。室温下,AC脂质体为乳白色细腻乳液,对室温条件稳定,但对光照和60℃不稳定。结论采用Box-Behnken实验设计法优化牛蒡苷pH敏感脂质体处方可得到较高包封率、稳定性优良且pH敏感性良好的产品,并为今后进行体内剂型研究奠定基础。
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| 关 键 词： | 牛蒡苷 pH敏感脂质体 薄膜分散法 Box-Behnken实验设计 |
Optimization of pH-sensitive arctiin liposome precription by Box-Behnken response surface methodology |
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| WU Xin-peng,SUN Li-yan,MU Hong-jie,YANG Shao-mei,WEI Jun-hua,ZHOU Xiu-di,CHEN Da-quan.Optimization of pH-sensitive arctiin liposome precription by Box-Behnken response surface methodology[J].qilu pharmaceutical affairs,2011,30(11):625-628. |
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| Authors: | WU Xin-peng SUN Li-yan MU Hong-jie YANG Shao-mei WEI Jun-hua ZHOU Xiu-di CHEN Da-quan |
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| Institution: | WU Xin-peng1,SUN Li-yan1,2,MU Hong-jie1,YANG Shao-mei1,WEI Jun-hua1,ZHOU Xiu-di1,CHEN Da-quan1(1.School of Pharmacy,Yantai University,Yantai 264005,China,2.Yantaishan Hospital,Yantai 264001,China) |
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| Abstract: | Objective To optimize and prepare pH-sensitive arctiin liposome by Box-Behnken response surface methodology.Methods The liposome was prepared by film dispersion method and optimized though a three factor and three-level Box-Behnken,with the lipid-cholesterol(X1),lipid-drug(X2) and the content of pH-sensitive materials(X3) as the independent variables,and the entrapment efficiency(Y1),drug loading(Y2),particle diameter(Y3) as the dependent variables.The stability of this praeparatum was investigated.Results ... |
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| Keywords: | Arctiin pH-sensitive liposome Membrane hydration method Box-Behnken experimntal design |
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