仙鹤草提取物镇痛抗炎试验的实验研究

目的:初步探讨中药仙鹤草提取物的镇痛抗炎作用.方法:取仙鹤草的水提取物和乙醇提取物,应用醋酸致小鼠扭体法、小鼠热板法、二甲苯致小鼠耳廓肿胀法和大鼠角叉菜胶足跖肿胀法研究其镇痛抗炎作用.结果:仙鹤草乙醇提取物和水提起物可减少醋酸致小鼠扭体次数,延长小鼠舔足时间,减轻二甲苯致小鼠耳廓肿胀程度,减小角叉菜胶致足跖肿胀程度;乙醇提取物作用强于水提取物.结论:中药仙鹤草乙醇提取物具有明显的镇痛抗炎作用.

Experimental studies of anti-inflammatory and analgesic effects of extract from Herba agrimoniae

Objective:To investigate the anti-inflammatory and analgesic effects of extract of Herba agrimoniae.Methods:The anti- inflammatory and analgesic effects of alcohol extract and water extract from Herba agrimoniae were observed by means of acetic acid in- ducing mouse writhing model,hot plate method,dimethylbenzene inducing ear edema model and carrageenan inducing rat voix pedis swell model.Results:It was found that alcohol extract and water extract from Herba agrimoniae markedly reducing the writhing fre- quency induced by acetic acid,significantly increasing the pain threshold in mice induced by hot plate,evidently suppressing the mouse's ear edema induced by dimethylbenzene and significantly mitigating the rat voix pedis swell inducing by carrageenan.The action of alcohol extract was better than which of water extract.Conclusion:The alcohol extract from Herba agrimoniae has notable effects on anti-inflammation and analgesia.