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丹参素对大鼠急性心肌缺血的保护作用
引用本文:陆文铨,张国强,陈大贵,张川.丹参素对大鼠急性心肌缺血的保护作用[J].药学实践杂志,2010,28(4):279-282.
作者姓名:陆文铨  张国强  陈大贵  张川
作者单位:1. 上海长征医院药学部,上海,200003
2. 解放军73841部队卫生处,江苏,南京210002
3. 第二军医大学药学院,上海,200433
摘    要:目的研究丹参素对大鼠急性心肌缺血的保护作用。方法采用垂体后叶素、异丙肾上腺素和冠脉结扎造成大鼠急性心肌缺血模型,以心电图T波变化,血清CK、LDH为指标,研究丹参素对大鼠急性心肌缺血的保护作用。结果丹参素(6、12、24mg/kg)剂量组均能对抗垂体后叶素及异丙肾上腺素引起的大鼠急性心肌缺血T波偏移,并且能够保护心肌细胞,显著降低冠脉结扎造成急性心肌缺血大鼠血清中CK和LDH溢出。结论丹参素对大鼠急性心肌缺血具有显著的保护作用。

关 键 词:急性心肌缺血  丹参素  垂体后叶素  异丙肾上腺素
收稿时间:2009/12/7 0:00:00
修稿时间:1/5/2010 12:00:00 AM

Protective effects of Danshensu on acute myocardial ischemia in rats
LU Wen-quan,ZHANG Guo-qiang,CHEN Da-gui and ZHANG Chuan.Protective effects of Danshensu on acute myocardial ischemia in rats[J].The Journal of Pharmaceutical Practice,2010,28(4):279-282.
Authors:LU Wen-quan  ZHANG Guo-qiang  CHEN Da-gui and ZHANG Chuan
Institution:Changzheng Hospital,Second Military Medical University,Shanghai 200433,China;Section of Health,73841th Unit of PLA,Nanjing 210002,China;School of pharmacy,Second Military Medical University,Shanghai 200433,China;School of pharmacy,Second Military Medical University,Shanghai 200433,China
Abstract:Objective To study the protective effects of Danshensu(Dan) on acute myocardial ischemia in rats. Methonds Acute myocardial ischemia rats were induced by injection of Iso and Pit. The height changes of T wave in ECG were examined. The levels of LDH,CK in serum were measured. Results Dan (6,12,24 mg/kg ) can significantly inhibit the height changes of T wave,obviously decrease the level of LDH, CK in the serum. Conclusion The results indicate that Dan has protective effects on acute myocardial isehemia in rats.
Keywords:acute myocardial ischemia  Danshensu  pituitrin  isoproterenol
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