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多效防护霜的处方优化
引用本文:韩凌,樊莉,张翮,吕磊,邹豪,鲁莹.多效防护霜的处方优化[J].药学实践杂志,2019,37(2):135-140,150.
作者姓名:韩凌  樊莉  张翮  吕磊  邹豪  鲁莹
作者单位:海军军医大学药学院药剂学教研室, 上海 200433,海军军医大学药学院药剂学教研室, 上海 200433,海军军医大学药学院药剂学教研室, 上海 200433,海军军医大学附属东方肝胆外科医院药材科, 上海 200438,海军军医大学药学院药剂学教研室, 上海 200433,海军军医大学药学院药剂学教研室, 上海 200433
基金项目:国家科技重大专项资助项目(2018ZX09J18110-001-001)
摘    要:目的 研制一款具有防水、防晒、防水母蜇伤的多效防护霜,并对其处方进行优化,使其具有较好的防水性能和较高的防晒指数(SPF值),同时具有适宜的黏度和较好的稳定性。方法 通过测定SPF值、关键波长和防水性能对处方中的成膜剂吡咯烷酮/十六烯共聚物(Antaron V-216)的质量分数进行优化。然后以黏度、离心稳定性和冻融稳定性为考察指标,使用星点设计-效应面法对多效防护霜中的两种乳化剂和氯化钙水溶液的质量分数进行优化。结果 当成膜剂Antaron V-216质量分数为3%时,霜剂的SPF值提升较为显著。当乳化剂月桂基聚乙二醇/聚丙二醇-18/18二甲基硅氧烷(DC5200)质量分数为0.76%,乳化剂鲸蜡基聚乙二醇/聚丙二醇-10/1二甲基硅氧烷(EM180)质量分数为2.32%,氯化钙水溶液质量分数为44.86%时,霜剂具有适宜的黏度和较好的稳定性。结论 经过优化的处方具有较高的防水性能和SPF值,黏度适宜,稳定性较好。

关 键 词:防晒剂  水母  蜇伤  防护制剂  防晒指数  效应面法
收稿时间:2018/10/29 0:00:00
修稿时间:2019/1/2 0:00:00

Formulation optimization for multi-purpose protective cream
HAN Ling,FAN Li,ZHANG He,L&#; Lei,ZOU Hao and LU Ying.Formulation optimization for multi-purpose protective cream[J].The Journal of Pharmaceutical Practice,2019,37(2):135-140,150.
Authors:HAN Ling  FAN Li  ZHANG He  L&#; Lei  ZOU Hao and LU Ying
Institution:Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China,Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China,Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China,Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200438, China,Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China and Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China
Abstract:Objective To develop a multi-purpose protective cream with waterproof,sunscreen and jellyfish sting protection and optimize the formulation to provide good water resistance,high SPF,suitable viscosity and good stability.Methods The mass fraction of the film former VP/Hexadecene copolymer (Antaron V-216) in the formulation was optimized through the measurement of SPF value,critical wavelength and water resistance.Based on viscosity,centrifugal stability and freeze-thaw stability,the central composite design-response surface method was used to optimize the mass fraction of two emulsifiers and CaCl2 aqueous solution in the cream.Results When the film former Antaron V-216 has a mass fraction of 3%,the SPF value of the cream is significantly increased.When the mass fraction of emulsifier lauryl PEG/PPG-18/18 methicone (DC5200) is 0.76%,the mass fraction of emulsifier cetyl PEG/PPG-10/1 dimethicone (EM180) is 2.32% and the mass fraction of CaCl2 aqueous solution is 44.86%,the cream has suitable viscosity and good stability.Conclusion The optimized formulation has high water resistance and SPF value,suitable viscosity and good stability.
Keywords:sunscreens  jellyfish  nematocyst  protective agent  SPF  response surface method
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