| 脂解模型在脂质给药系统体外评价中的应用研究进展 |
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| 引用本文： | 曾棋平,张晶,刘志宏,宋洪涛.脂解模型在脂质给药系统体外评价中的应用研究进展[J].药学实践杂志,2014,32(2):85-87. |
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| 作者姓名： | 曾棋平 张晶 刘志宏 宋洪涛 |
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| 作者单位： | [1]南京军区福州总医院药学科,福建福州350025 [2]福建医科大学药学院,福建福州350108 |
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| 基金项目： | 福建省自然科学基金（2010J01218）. |
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| 摘 要： | 目的 综述脂解模型的组成及其在脂质制剂体外评价的应用,为推动脂质制剂的发展提供参考.方法 通过查阅近年来国内外相关文献,归纳、分析和总结.结果 体外脂解模型能准确反映脂质制剂在人体内的性质,建立良好的体内外相关性.结论 脂解模型用于筛选和评价脂质制剂具有良好的应用前景.
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| 关 键 词： | 脂解模型 脂质制剂 体内外相关性 筛选 |
| 收稿时间： | 2013/4/25 0:00:00 |
| 修稿时间： | 2013/11/4 0:00:00 |
In vitro evaluation of lipid drug delivery system by lipolysis model |
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| ZENG Qiping,ZHANG Jing,LIU Zhihong and SONG Hongtao.In vitro evaluation of lipid drug delivery system by lipolysis model[J].The Journal of Pharmaceutical Practice,2014,32(2):85-87. |
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| Authors: | ZENG Qiping ZHANG Jing LIU Zhihong and SONG Hongtao |
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| Institution: | 1. Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China; 2. School of Pharmacy, Fujian Medical University, Fuzhou 350108, China) |
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| Abstract: | Objective To review the composition of lipolysis model and the application in the in vitro evaluation of lipid for- mulations, provide reference for promoting the development of lipid formulations. Methods Recent relevant literatures were analyzed and summarized. Results In vitro lipolysis model could accurately reflect the in vivo nature of lipid formulations, and a good correla- tion between in vivo and in vitro could be established. Conclusion There is a good prospect in using lipolysis model for screening and evaluation of lipid formulations. |
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| Keywords: | lipolysis model lipid formulations in vitro-in vivo correlation screening |
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