| 盐酸坦索罗辛缓释制剂的研究进展 |
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| 引用本文： | 柴佩华,张涛,高申.盐酸坦索罗辛缓释制剂的研究进展[J].药学实践杂志,2016,34(6):493-496. |
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| 作者姓名： | 柴佩华 张涛 高申 |
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| 作者单位： | 第二军医大学附属长海医院药学部, 上海 200433;赢创特种化学(上海)有限公司, 上海 201108,赢创特种化学(上海)有限公司, 上海 201108,第二军医大学附属长海医院药学部, 上海 200433 |
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| 摘 要： | 盐酸坦索罗辛广泛用于治疗良性前列腺增生症的下尿路症状，需要长期用药。口服盐酸坦索罗辛因药物吸收快、起效快，常导致低血压和眩晕等不良反应，故临床上建议应用其缓释制剂。目前国内外上市的盐酸坦索罗辛缓释制剂主要为缓释胶囊和缓释片，如Flomax®，Harnal®，国内仍以原研制剂Harnal®缓释胶囊占有主要市场，鉴于该药良好的市场前景，对其缓释制剂的研究也越来越多。本文就盐酸坦索罗辛缓释制剂的研究进展做一综述。
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| 关 键 词： | 盐酸坦索罗辛 缓释制剂 |
| 收稿时间： | 2015/10/21 0:00:00 |
| 修稿时间： | 2016/4/26 0:00:00 |
Progress of tamsulosin hydrochloride sustained-release preparation |
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| CHAI Peihu,ZHANG Tao and GAO Shen.Progress of tamsulosin hydrochloride sustained-release preparation[J].The Journal of Pharmaceutical Practice,2016,34(6):493-496. |
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| Authors: | CHAI Peihu ZHANG Tao and GAO Shen |
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| Institution: | Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Evonik Specialty Chemicals(Shanghai) Co., Ltd., Shanghai 201108, China,Evonik Specialty Chemicals(Shanghai) Co., Ltd., Shanghai 201108, China and Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Tamsulosin hydrochloride is widely used for the treatment of lower urinary tract symptoms of benign prostatic hyperplasia, requiring long-term medication. It reduces adverse reactions of hypotension and dizziness by rapid absorption from oral intake. The sustained-release (SR) formulation is recommended for clinical application. Currently in domestic and foreign market, SR products mainly include SR capsules and SR tablets, like Flomax® and Harnal®. The domestic market mainly uses the originally developed Harnal® SR capsules. In accordance with the drug''s potential market, more and more SR studies have been done. This article reviews the research progress of tamsulosin hydrochloride sustained-release preparation. |
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| Keywords: | tamsulosin hydrochloride(TSH) sustained-release preparation |
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