| 真菌多药耐药外排机制的研究进展 |
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| 引用本文： | 康烨,周密,阎澜.真菌多药耐药外排机制的研究进展[J].药学实践杂志,2016,34(6):485-488. |
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| 作者姓名： | 康烨 周密 阎澜 |
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| 作者单位： | 原沈阳军区总医院北陵临床部, 辽宁 沈阳 110031,解放军152医院, 河南 平顶山 467000,第二军医大学药学院新药研究中心, 上海 200433 |
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| 基金项目： | 国家自然科学基金面上项目（81470158） |
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| 摘 要： | 真菌多药耐药性是指真菌细胞对结构不同、作用靶点不同的药物同时具有耐药性的现象，是导致临床抗真菌治疗失败的重要原因之一。本文综述了酿酒酵母、条件致病真菌白假丝酵母、光滑假丝酵母和烟曲霉中多药耐药相关转运蛋白、药物外排机制以及基因表达调控网络的研究进展，旨在为深入了解真菌多药耐药性的机制、探讨克服多药耐药性的策略和提高抗真菌药物的药效提供参考。
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| 关 键 词： | 真菌 多药耐药 外转运蛋白 |
| 收稿时间： | 2015/6/29 0:00:00 |
| 修稿时间： | 2016/4/28 0:00:00 |
Progress of the drug efflux mechanisms underlying fungi multidrug resistance |
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| KANG Ye,ZHOU Mi and YAN Lan.Progress of the drug efflux mechanisms underlying fungi multidrug resistance[J].The Journal of Pharmaceutical Practice,2016,34(6):485-488. |
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| Authors: | KANG Ye ZHOU Mi and YAN Lan |
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| Institution: | Beiling Clinical Department, General Hospital of Shenyang Military Region, Shenyang 110031, China,No. 152 Hospital of PLA, Pingdingshan 467000, China and New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | The multidrug resistance (MDR), characterized by the simultaneous acquisition of resistance to chemically and structurally different drugs, has caused antifungal treatment failure. This review focused on recent progresses in understanding of the multidrug resisitance associated drug efflux transporter superfamily in Saccharomyces cerevisiae, the opportunistic fungal pathogens Candida albicans, Candida glabrata, and Aspergillus fumigates, along with the mechanisms underlying efflux pump and the regulatory networks involved. Investigation of these mechanisms and their impact on drug resistance may lead to strategies to overcome fungal multidrug resistance and improvement of drug efficacy. |
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| Keywords: | fungus multidrug resistance multidrug efflux transporters |
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