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气滞胃痛颗粒促进胃肠运动和镇痛作用研究
引用本文:李晏,陈渊源,伊佳,蒋红,沈甫明. 气滞胃痛颗粒促进胃肠运动和镇痛作用研究[J]. 药学实践杂志, 2009, 27(2): 90-93
作者姓名:李晏  陈渊源  伊佳  蒋红  沈甫明
作者单位:1. 中国人民解放军第411医院药剂科,上海,200081
2. 第二军医大学药学院药理学教研室,上海,200433
摘    要:目的:观察气滞胃痛颗粒对小鼠胃肠动力的影响和镇痛作用,为气滞胃痛颗粒的临床合理应用提供理论依据。方法:以胃肠内标记物葡聚糖蓝-2000在小鼠胃内色素残留及小肠内推进比为指标,观察气滞胃痛颗粒对小鼠胃排空及肠推进的影响;以醋酸所致小鼠扭体反应为疼痛指标,观察气滞胃病颗粒的镇痛作用。结果:气滞胃痛颗粒低、中、高剂量组(1.25g/kg、2.50g/kg、5.00g/kg)可以改善阿托品和多巴胺引起的小鼠胃排空障碍、以及小肠推进抑制作用;对吗啡引起的小鼠胃排空障碍和小肠推进抑制作用无显著影响;中、高剂量组可以促进正常小鼠胃排空,高剂量促进小肠推进。低、中、高剂量组可以显著减少醋酸引起的小鼠扭体次数。结论:气滞胃痛颗粒具有促进小鼠胃肠动力和镇痛作用。

关 键 词:气滞胃痛颗粒  胃肠功能  镇痛
收稿时间:2008-11-24

Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice
Li Yan,Chen Yuan-yuan,Yin Ji,Jiang Hong and Shen Fu-ming. Effects of Qizhiweitong granule on gastrointestinal function and analgesic action in mice[J]. The Journal of Pharmaceutical Practice, 2009, 27(2): 90-93
Authors:Li Yan  Chen Yuan-yuan  Yin Ji  Jiang Hong  Shen Fu-ming
Affiliation:Department of Pharmacy, 411th Hospital of PLA, Shanghai 200081, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Abstract:Objective: To investigate the action of Qizhiweitong granule(QZ) on gastrointestinal function and analgesic effect in mice.Methods: Dextran blue-2000 was used as a marker,both its residue left in the stomach and propulsion velocity in the intestine were determined for the evaluation of gastrointestinal function;with acetic acid induced mice writhing response model,analgesic effect of QZ was determined.Results: QZ 1.25 g/kg,2.50 g/kg,5.00 g/kg improved the inhibition of gastric empty and intestinal propulsion induced by both atropine and dopamine.No changes were observed in morphine-induced gastrointestinal disorder mice model.All the three doses exhibited analgesic effect on acetic acid induced mice writhing response model.Conclusion:These results suggest QZ maybe used to improve gastrointestinal function and possessed analgesic effects.
Keywords:Qizhiweitong granule   gastrointestinal function   analgesic effect
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