| P53-MDM2界面的肽类及拟肽类抑制剂的研究进展 |
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| 引用本文： | 李翔,邹燕,吴茂诚,黄婷,胡宏岗,吴秋业.P53-MDM2界面的肽类及拟肽类抑制剂的研究进展[J].药学实践杂志,2015,33(6):494-497,512. |
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| 作者姓名： | 李翔 邹燕 吴茂诚 黄婷 胡宏岗 吴秋业 |
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| 作者单位： | 第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433 |
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| 摘 要： | 当前,肿瘤疾病以日益增高的发病率越来越受到人们的重视。抑制P53-MDM2的相互作用已经成为治疗癌症药物设计的重要靶标,通过各种药物筛选手段,研究人员发现了许多肽类及小分子抑制剂。综述近年来国内外关于肽类及拟肽类的P53-MDM2抑制剂的研究进展。
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| 关 键 词： | P53-MDM2 肽 抑制剂 |
| 收稿时间： | 2013/11/25 0:00:00 |
| 修稿时间： | 2014/3/31 0:00:00 |
Research progress of inhibitors of peptides and peptidomimetic acting on P53-MDM2 interface |
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| LI Xiang,ZOU Yan,WU Maocheng,HUANG Ting,HU Honggang and WU Qiuye.Research progress of inhibitors of peptides and peptidomimetic acting on P53-MDM2 interface[J].The Journal of Pharmaceutical Practice,2015,33(6):494-497,512. |
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| Authors: | LI Xiang ZOU Yan WU Maocheng HUANG Ting HU Honggang and WU Qiuye |
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| Institution: | Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China and Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Tumor diseases have attracted great attention of the society because of the increasing morbidity in recent years. To inhibit the P53-MDM2 interaction has become an important target for design of cancer drug, and a lot of peptide and small molecule inhibitors have been found with various kinds of drug screening and research tools. This paper summarized the recent progress of the peptide and peptidomimetic inhibitors of P53-MDM2 at home and abroad lately. |
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| Keywords: | P53-MDM2 peptide inhibitor |
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