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慢性阻塞性肺疾病患者血栓前状态的研究
引用本文:薛旗山,原永平,刘亚峰,赵秋红,郑力,雷芸,张平.慢性阻塞性肺疾病患者血栓前状态的研究[J].中国医药,2007,2(1):4-5.
作者姓名:薛旗山  原永平  刘亚峰  赵秋红  郑力  雷芸  张平
作者单位:100076,北京航天总医院呼吸内科
摘    要:目的探讨慢性阻塞性肺疾病(COPD)患者的血液凝血系统功能的改变。方法采集COPD急性加重期患者82例、稳定期患者25例和20例正常对照者的外周静脉血,测定D-二聚体、纤维蛋白原(Fb)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血时间(TT)。结果COPD急性加重期组与稳定期组比较,D-二聚体、Fb、PT、APTT、TT间差异无显著性。较正常对照组比较,D-二聚体和Fb水平升高,差异有显著性。COPD重度患者与轻中度患者间比较,D-二聚体和Fb水平差异有显著性(P<0.01)。结论COPD急性加重期和稳定期患者,凝血系统加强,抗凝系统减弱,存在血栓前状态。

关 键 词:慢性阻塞性肺疾病  D-二聚体  纤维蛋白原
文章编号:1673-4777(2007)01-0004-02
收稿时间:2006-08-17

Prethrombolic state of patients with chronic obstructive pulmonary disease.
Xue Qishan, Yuan Yongping ,Liu Yafeng ,et al..Prethrombolic state of patients with chronic obstructive pulmonary disease.[J].China Medicine,2007,2(1):4-5.
Authors:Xue Qishan  Yuan Yongping  Liu Yafeng  
Institution:Xue Qishan, Yuan Yongping ,Liu Yafeng , et al.
Abstract:Objective To study the function changes of coagulation system in patients with chronic obstructive pulmonary disease(COPD).Methods The peripheral vein blood samples were taken from 82 COPD cases at acute worsening period,25 stable cases and 20 normal controls for the determination of D-dimer,Fibrinogen(Fb),Prothrombin time(PT),Activated partial thromboplastin time(APTT) and thrombin time(TT).Results D-dimer,Fb,PT,APTT and TT were not significantly different between acute worsening COPD patients and stable patients but D-dimer and Fb level were higher in acute worsening COPD patients than normal controls.D-dimer and Fb level were significantly different between severe COPD patients and slight and mediate COPD patients(P<0.01).Conclusion Coagulation function is strengthened and anti-coagulation system is weakened in acute worsening and stable COPD patients,in whom prethrombolic state exists.
Keywords:Chronic obstructive pulmonary disease  D-dimer  Fibrinogen
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